摘要
目的了解微波消融技术联合经皮肝动脉化疗栓塞术(TACE)的临床疗效及其对机体免疫功能、AFP及生存期的影响。方法收集本院2015年1月至2018年1月经治中晚期肝癌100例,依据抽签法将所有患者分为观察组与对照组。对照组:单纯给予TACE;观察组:给予微波消融联合TACE。所有患者治疗前与治疗后各查1次淋巴细胞亚群分析、血清AFP。术后随访1年,采用电话随访的方式,每2个月随访1次,随访结局事件为死亡,记录患者相应的生存时间、复发情况及术后各类不良事件等。对两组所得数据进行对比分析。结果观察组治疗后CD4^(+)T细胞及NK细胞治疗后占比均高于对照组,差异具有统计学意义(P均<0.05)。观察组治疗后CD8^(+)T细胞治疗后占比高于对照组,差异具有统计学意义(P<0.05)。观察组治疗后CD4^(+)T细胞、CD8^(+)T细胞及NK细胞治疗后占比均高于治疗前,差异具有统计学意义(P均<0.05)。两组治疗后血清AFP水平均低于治疗前,差异具有统计学意义(P均<0.05)。观察组治疗后血清AFP水平低于对照组,差异具有统计学意义(P<0.05)。观察组术后1年生存率高于对照组,差异具有统计学意义(P<0.05)。两组术后1年复发率差异无统计学意义(P>0.05)。两组术后1年白细胞减少、血小板减少、咯血及上消化道出血等不良事件发生率差异无统计学意义(P均>0.05)。结论微波消融联合TACE可有效改善中晚期肝癌患者的免疫功能,降低其血清AFP水平及复发率,提高整体生存率。
Objective To learn the clinical efficacy of microwave ablation combined with percutaneous transcatheter arterial chemoemholization(TACE)ami its effects on immune function,AFP and survival.Method 100 cases of advanced liver cancer,treated in our hospital from January 2015 to January 2018,were collected.All patients were divided into observation group and control group according to the drawing method.Control group:TACE alone;observation group:microwave ablation combined with TACE.All patients were examined for lymphocyte subsets and scrum AFP before and after treatment.All patients were followed up for 1 year.All patients were followed up every 2 months by telephone follow-up.The outcome was followed by death.The corresponding survival time,recurrence and various adverse events were recorded.Comparative analysis was performed on the data obtained beetween the two groups.Results The proportion of CD4^(+)T cells and NK cells after treatment in the observation group was higher than that in the control group(P<0.05).The proportion of CD8^(+)T cells after treatment in the observation group was higher than that of the control group(P<0.05).The proportion of CD4^(+)T cells,CD8^(+)T cells and NK cells after treatment in the observation group was higher than that before treatment(P<0.05).The serum AFP levels in the two groups were lower than those before treatment(P<0.05).The serum AFP level in the observation group was lower than that in the control group after treatment(P<0.05).The 1-year survival rate of the observation group was higher than that of the control group(P<0.05).There was no significant difference in the recurrence rate between the two groups(P>0.05).There was no significant difference in the incidence of adverse events such as leukopenia,throml>o-cylopenia,hemoptysis and upper gastrointestinal bleeding between the two groups(P>0.05).Conclusion microwave ablation combined with percutaneous transcatheter arterial chemoembolization(TACE)can improve immune function of patients,decrease AFP level and imp
作者
封冰
王伟
翟景明
姚国良
范永刚
FENG Bing;WANG Wei;ZHAI Jing-ming(The First Hospital of Henan Science and Technology University,Zhenzhou 471000,China)
出处
《肝胆外科杂志》
2021年第2期142-145,共4页
Journal of Hepatobiliary Surgery
关键词
中晚期肝癌
微波消融
经肝动脉栓塞术
疗效
免疫功能
AFP
生存期
advanced liver cancer
microwave ablation
transcatheter arterial embolization
efficacy
immune function
AFP
survival
