摘要
本研究探讨了肝动脉化学治疗栓塞联合超声引导下微波消融术治疗特殊部位肝癌的临床意义，具有创新性，有临床实用价值。依然存在的主要问题为：（1）特殊部位与普通部位肿瘤微波消融时间及功率不一致，是否对研究结果有影响？（2）该研究中是否存在多次肝动脉经导管化学治疗栓塞及多次微波消融的情况，文章中应该有所体现，并分析其对研究结果的影响。
Objective To investigate the efficacy and clinical value of transcatheter arterial chemoembolization （TACE） combined with ultrasound-guided microwave ablation for the treatment of liver cancer in special sites. Methods The patients with liver cancer in special sites （the liver cancer was adjacent to the gallbladder, dome of diaphragm, gastrointestinal tract, heart, great vessels, and portal vein, with the shortest distance from the tumor to the organ/lumen 〈 0.5 cm ） were enrolled as treatment group, and the patients with primary liver cancer in normal sites treated in our hospital during the same period were randomly enrolled as control group. They underwent TACE combined with ultrasound-guided microwave ablation. The 6-month, 12-month, 18-month and 24-month survival rates of the patients in two groups were analyzed. Results The clinical data of 40 patients with liver cancer in special sites, including 9, 7, 5, 11, 3, 3, and 2 patients with liver cancer adjacent to the gallbladder, dome of diaphragm, gastrointestinal tract, portal vein, hepatic vein, inferior vena cava, and heart, respectively, and another 40 patients in control group were collected in the study. The negative rate of alpha-fetoprotein （AFP） was 83.3% in the treatment group and 82.8% in the control group. The 6-month, 12-month, 18-month, and 24-month survival rates were 100.0%, 95.0%, 90.0%, and 80.0%, respectively, in the treatment group, and 100.0%, 97.5%, 92.5%, and 85.0%, respectively, in the control group. Conclusion TACE combined with ultrasound-guided microwave ablation is as effective for liver cancer in special sites as for those in normal sites, with high safety, and is feasible in clinical application.
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2017年第12期914-919,共6页
Chinese Journal of Hepatology
关键词
肝动脉
栓塞
消融技术
肝肿瘤
Hepatic artery
Embolism
Ablation techniques
Liver neoplasms
