摘要
目的探讨经导管化疗栓塞(TACE)联合经皮微波消融治疗(PMCT)中晚期肝癌的临床疗效。方法根据治疗方法的不同将75例中晚期肝癌患者分为观察组(n=43)和对照组(n=32),对照组患者单纯行TACE治疗,观察组患者采用TACE联合PMCT治疗。观察2组近期疗效和不良反应,治疗前后甲胎蛋白(AFP)和肝功能指标谷丙转氨酶(ALT)、谷草转氨酶(AST)变化;随访24个月,观察2组患者6、12、18和24个月存活率和累计复发转移率。结果观察组缓解率为65.91%,显著高于对照组的43.75%,差异有统计学意义(P<0.05);观察组肝区痛,出汗发生率显著高于对照组(P<0.05);2组治疗后AFP和肝功能指标均较治疗前明显降低,差异有统计学意义(P<0.05),且观察组治疗后AFP显著低于对照组(P<0.05);观察组18个月和24个月时生存率显著高于对照组(P<0.05),观察组12个月、18个月和24个月时累积复发率显著低于对照组(P<0.05)。结论 TACE联合PMCT治疗中晚期肝癌近期疗效显著,能提高患者生存率,降低累积复发率,但会增加肝区痛等不良反应的发生。
Objective To explore the curative effect of patients with Terminal-stage liver cancer by transcatheter arterial chemo embolization combined with Percutaneous microwave coagulation therapy. Methods 75 patients with middle-late liver cancer were divided into observation group（ n = 43） and the control group（ n = 32） according to different therapeutic methods,patients in control group were treated with simple TACE,while patients in observation group were treated with TACE combined with PMCT. Compared the curative effect in the near future and adverse reaction,α-fetoprotein（ AFP）,liver function index between two groups. Follow-up for 24 months,observed the survival time 6,12,18 and 24 months after treatment and the recurrence of cumulative transfer rate between two groups. Results The response rate（ RR） in observation group was 65. 91%,it was significantly higher than that of control group（ P〈0. 05）; The liver area pain,sweating rate in observation group was significantly higher than control group（ P〈0. 05）; The AFP,ALT and AST after treatment in both groups were significantly lower than those before treatment（ P〈0. 05）,AFP after treatment in observation group was significantly lower than that in the control group（ P〈0. 05）; The survival rate 18 months and 24 months after treatment in observation group was significantly higher than that of control group（ P〈0. 05）,the cumulative recurrence rate 12 months,18 months and 24 months after treatment in observation group was significantly lower than control group（ P〈0. 05）. Conclusion Patients with terminal-stage liver cancer treated with TACE combined with PMCT can get better near future curative effect,it can improve survival time,reduce the cumulative recurrence rate but can increase the liver area pain.
出处
《中华全科医学》
2015年第5期731-733,共3页
Chinese Journal of General Practice
关键词
肝动脉化疗栓塞
经皮微波消融治疗
中晚期肝癌
疗效
Transcatheter arterial chemo embolization
Percutaneous microwave coagulation therapy
Terminal-stage liver cancer
Curative effect
