摘要
目的探讨依达拉奉联合多巴丝肼应用于血管源性帕金森综合征(VP)患者的效果。方法选取我院VP患者86例,依据随机数字表法分为对照组和观察组,每组43例。对照组采用多巴丝肼治疗,观察组在对照组基础上联合依达拉奉治疗。比较两组疗效、治疗前及治疗20 d后抗氧化能力[血清过氧化氢酶(CAT)、总抗氧化能力(TAC)]、帕金森病评定量表(UPDRS)评分以及不良反应发生率。结果观察组治疗总有效率高于对照组(P<0.05);治疗20 d后,观察组血清CAT、TAC水平高于对照组(P<0.05);治疗20 d后,观察组日常生活能力、精神行为情绪、运动能力等维度UPDRS评分低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论依达拉奉联合多巴丝肼治疗VP疗效显著,可增强抗氧化能力,减轻病情,改善认知功能,提高日常生活能力,且安全性高。
Objective To explorethe effect of edaravone combined with levodopa and benserazidein the treatment of patients with vascular Parkinson’s syndrom(VP).Methods A total of 86 VP patients in our hospital were selected and randomly divided into the control group and the observation group,43 cases in each group.The control group was treated with levodopa and benserazide and the observation group was treated with edaravone on the basis of the control group.The efficacy,antioxidant capacity[serum catalase(CAT),total antioxidant capacity(TAC)]before treatment and 20 d after treatment,Parkinson’s disease rating scale(UPDRS)scores and the incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group(P<0.05).After 20 days of treatment,the serum CAT and TAC levels of the observation group were higher than those in the control group(P<0.05);the ability of daily living,the UPDRS scores of mental,behavior,mood,exercise ability and other dimensions were lower than those of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of edaravone with levodopa and benserazide has a significant effect in the treatment of VP,which can enhance the antioxidant capacity,relieve the disease,improve cognitive function,improve the ability of daily living and has high safety.
作者
董歌
DONG Ge(The 83rd Group Army Hospital of the Chinese People's Liberation Army,Xinxiang 453000,Henan)
出处
《菏泽医学专科学校学报》
2021年第2期18-20,共3页
Journal of Heze Medical College
关键词
依达拉奉
多巴丝肼
血管源性帕金森综合征
帕金森病
Edaravon
Levodopa and benserazide
Vascular Parkinson’s syndrome
Parkinson’s Disease
