摘要
目的研究探讨清热祛浊胶囊联合胰岛素强化治疗对痰湿瘀热型2型糖尿病患者的临床疗效及炎性因子水平的影响。方法:收集2018年4月—2020年4月本院门诊收治的痰湿瘀热型2型糖尿病患者108例为调查研究对象,随机分为观察组(54例)、对照组(54例),对照组给予胰岛素强化治疗,观察组采用清热祛浊胶囊联合胰岛素强化治疗干预。连续治疗3个疗程后对2组患者的临床疗效、血糖指标、炎性因子水平、血管内皮功能、不良反应发生率等进行统计对比。结果观察组自愿退出本研究1例、未严格执行用药方案2例;对照组失访1例、检测结果缺失1例剔除本研究。观察组总有效率为88.24%(45/51),高于对照组患者为71.15%(37/52)(P<0.05)。治疗后观察组患者的血糖指标包括糖化血红蛋白(Hb A1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)水平均低于对照组(P<0.05)。治疗后观察组患者的炎性因子包括单核细胞趋化蛋白-1(MCP-1)、白介素-1β(IL-1β)、高迁移率族蛋白B1(HMGB1)水平均低于对照组(P<0.05)。治疗后观察组血管内皮功能指标包括血管内皮素1(ET-1)低于对照组,而一氧化氮(NO)、内皮依赖性血管舒张功能指数(FMD)水平高于对照组(P<0.05)。治疗期间观察组、对照组不良反应发生率分别为17.65%(9/51)、11.54%(6/52),组间比较无差异(P>0.05)。结论清热祛浊胶囊联合胰岛素强化治疗对痰湿瘀热型2型糖尿病患者治疗效果显著,能够改善患者的糖代谢指标,降低机体的炎性因子水平,改善患者的血管内皮功能,治疗安全性良好,可临床推广。
Objective To study the effect of Qingre Quzhuo Capsules combined with the intensive insulin therapy on the clinical efficacy and inflammatory factor levels in type 2 diabetes mellitus patients with the pattern of phlegm dampness and blood stasis heat.Methods A total of 108 type 2 diabetes mellitus patients patients with the phlegm dampness and blood stasis heat pattern admitted in our hospital from April 2018 to April 2020 were selected as the research subjects and randomly divided into observation group(54 cases)and control group(54 cases).The control group was treated with the intensive insulin therapy,while the observation group was treated with Qingre Quzhuo Capsules combined with the intensive insulin therapy.After 3 courses of consecutive treatment,the clinical efficacy,blood glucose index,inflammatory factor level,vascular endothelial function,and incidence of adverse reactions were statistically compared between the two groups.Results One case in the observation group voluntarily withdrew from the study,and two cases did not strictly implement the medication plan.One case in the control group was lost to follow-up,and one case with missing test results was excluded from the study.The total effective rate of the observation group was 88.24%(45/51),significantly higher than 71.15%(37/52)of the control group(P<0.05).After treatment,the blood glucose indexes of glycosylated hemoglobin(HbA1c),fasting insulin(FINS),and insulin resistance index(HOMA-IR)of the observation group were lower than those of the control group(P<0.05).After treatment,the inflammatory factors levels of monocyte chemoattractant protein-1(MCP-1),interleukin-1β(IL-1β),and high mobility group protein B1(HMGB1)in the observation group were lower than those in the control group(P<0.05).After treatment,the vascular endothelial function indexes of vascular endothelin 1(ET-1)of the observation group were lower than those of the control group,while the levels of nitric oxide(NO)and endothelium-dependent vasodilation index(FMD)were higher(P<0.05)
作者
尹金秀
YIN Jinxiu(Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061000,China)
出处
《吉林中医药》
2021年第6期780-783,共4页
Jilin Journal of Chinese Medicine
基金
河北省中医药管理局科研计划项目(2018495)。
关键词
2型糖尿病
痰湿瘀热型
胰岛素强化治疗
清热祛浊胶囊
临床疗效
炎性因子
血管内皮功能
type 2 diabetes mellitus
pattern of phlegm dampness and blood stasis heat
intensive insulin therapy
Qingre Quzhuo Capsules
clinical efficacy
inflammatory factors
vascular endothelial function
