摘要
目的:观察长期负性情绪积累对化疗后三阴性乳腺癌患者认知功能、尿8-羟化脱氧鸟苷(8-hydroxylated deoxyguanosine,8-OHdG)及血浆超氧化物歧化酶(superoxide dismutase,SOD)、过氧化脂质(lipid peroxidation,LPO)的影响。方法:采用艾森克人格问卷(EPQ)N维度量表评估河南中医药大学第一附属医院血液肿瘤科门诊以及病房就诊的化疗后三阴性乳腺癌患者,筛选情绪稳定与不稳定患者,并按照同性别、同年龄段、同文化程度进行1∶1匹配,分为情绪稳定组和情绪不稳定组。采用蒙特利尔量表(Montreal cognitive assessment,MoCA)评估两组患者的认知功能,采用肝气郁结量表观察两组患者的肝气郁结程度,采用酶联免疫吸附法检测两组患者的尿8-OHdG及血浆SOD和LPO水平。结果:情绪不稳定组患者认知功能明显下降,与情绪稳定组比较,差异有统计学意义(P<0.05)。情绪不稳定组视空间与执行、注意、语言、延迟回忆、定向得分明显下降,与情绪稳定组比较,差异有统计学意义(P<0.05)。情绪不稳定组肝气郁结证症状程度评分高于情绪稳定患者,差异有统计学意义(P<0.05)。情绪不稳定组尿8-OHdG、血浆LPO水平高于情绪稳定组,而情绪不稳定组的血浆SOD水平低于情绪稳定组,差异均有统计学意义(P<0.05)。结论:长期负性情绪积累是导致化疗后三阴性乳腺癌患者功能衰退的主要原因。
Objective:To observe the effects of long-term negative emotion accumulation on cognitive function,urinary 8-hydroxylated deoxyguanosine(8-OHdG),plasma superoxide dismutase(SOD),and lipid peroxidation(LPO)of post-chemotherapy patients with triple-negative breast cancer.Methods:Triple-negative breast cancer patients in the outpatient department and Hematology and Oncology Department of the First Affiliated Hospital of Henan University of CM were evaluated with EPQ N-dimension and disturbed into the emotionally stable and unstable group.All subjects were matched 1:1 according to the same gender,age,and education level.And MOCA was used to evaluate the cognitive function of the two groups,and the degree of liver Qi stagnation was observed with the liver Qi stagnation scale.The urinary 8-OHdG and plasma SOD and LPO levels of the two groups were detected by enzyme-linked immunosorbent assay.Results:The cognitive function of the emotionally unstable group decreased significantly,and the difference was statistically significant(P<0.05)compared with the emotionally stable group.The emotionally unstable group also had a significant decrease in visual space and execution,attention,language,delayed recall,and orientation scores.Compared with the emotionally stable group,the difference was statistically significant(P<0.05).The score of the symptom of liver Qi stagnation syndrome in the unstable group was higher than those of stable patients,and the difference was statistically significant(P<0.05).The level of urine 8-OHdG and plasma LPO level in the emotionally unstable group was higher than that in the stable group,while the Plasma SOD level in the unstable group was lower than that in the stable group,and the differences were statistically significant(P<0.05).Conclusion:Long-term accumulation of negative emotions is the main cause of the functional decline in triple-negative breast cancer patients after chemotherapy.
作者
关徐涛
徐立然
孙士玲
于冬冬
魏征
党辉
万姜维
徐江雁
张丹阳
GUAN Xutao;XU Liran;SUN Shiling;YU Dongdong;WEI Zheng;DANG Hui;WAN Jiangwei;XU Jiangyan;ZHANG Danyang(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou Henan China 450000;The Third Clinical Medicine College of Henan University of Chinese Medicine,Zhengzhou Henan China 450008;Henan Academy of Chinese Medicine,Zhengzhou Henan China 450004;Zhengzhou Traditional Chinese Medicine Hospital,Zhengzhou Henan China 450000)
出处
《中医学报》
CAS
2021年第6期1309-1314,共6页
Acta Chinese Medicine
基金
国家自然科学基金项目(81804196)
中国博士后基金面上项目(2017M612407)
国家中医临床研究基地专项课题项目(2018JDZX023,2019JDZX014)
河南省科技攻关项目(212102311136)
河南中医药科学研究专项课题项目(20-21ZY1010,20-21ZY2106)
河南中医药大学苗圃基金项目(MP2020-14)。
