摘要
目的:观察补肺益气平喘汤联合正压通气治疗肺肾亏虚合并痰热蕴肺型慢性阻塞性肺疾病急性加重期(AECOPD)合并严重Ⅱ型呼吸衰竭(RF)的临床价值及对肺功能的影响。方法:将72例肺肾亏虚合并痰热蕴肺型AECOPD合并严重RF患者分为2组,每组36例。常规组接受常规正压通气治疗,联合组接受补肺益气平喘汤联合正压通气治疗,比较2组血清炎性指标、动脉血气指标及肺功能指标变化情况。结果:与同组治疗前比较,2组治疗后血清C-反应蛋白(CRP)、血清降钙素原(PCT)水平减少(P<0.05),二氧化碳分压(PaCO2)下降(P<0.05),动脉氧分压(PaO2)上升(P<0.05);治疗7 d后2组气道阻力(R)及内源性呼气末正压(PEEPi)下降(P<0.05),肺顺应性(CST)上升(P<0.05)。与常规组治疗3 d后比较,联合组治疗3 d后血清CRP、PCT水平减少(P<0.05),PaCO2下降(P<0.05),PaO2上升(P<0.05),R及PEEPi下降(P<0.05),CST上升(P<0.05);与常规组治疗7 d后比较,联合组治疗7 d后血清CRP、PCT水平减少(P<0.05),PaCO2下降(P<0.05),PaO2上升(P<0.05),R及PEEPi下降(P<0.05),CST上升(P<0.05)。治疗后,联合组总有效率为86.11%,高于常规组的63.89%(P<0.05)。结论:补肺益气平喘汤联合正压通气可有效改善AECOPD合并严重RF的CST及气道状态,提高临床治疗效果。
Objective:To observe the clinical value of Bufei Yiqi Pingchuan tang combined with positive pressure ventilation for acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with severe typeⅡrespiratory failure(RF)of the lung-kidney deficiency and phlegm-heat obstructing the lung type,and its effect on the lung function.Methods:A total of 72 cases of patients with AECOPD complicated with severe RF of the lung-kidney deficiency and phlegm-heat obstructing the lung type were divided into two groups,36 cases in each group.The routine group was treated with routine positive pressure ventilation,and the combination group was treated with Bufei Yiqi Pingchuan tang combined with positive pressure ventilation.Changes in inflammatory markers in serum,arterial blood gas indexes and indexes of the lung function were compared between the two groups.Results:When compared with those in the same group before treatment,levels of C-reactive protein(CRP)and procalcitonin(PCT)in serum in the two groups were decreased after treatment(P<0.05);levels of partial carbon dioxide pressure(PaCO2)were decreased(P<0.05),and levels of partial aiterial oxygen pressure(PaO2)were increased(P<0.05).After seven-day treatment,airway resistance(R)and positive endexpiratory pressure(PEEPi)in the two groups were decreased when compared with those before treatment in the same group(P<0.05),and levels of static lung compliance(CST)were increased(P<0.05).After three-day treatment,when compared with those in the routine group,levels of CRP and PCT in serum in the combination group were decreased(P<0.05);level of PaCO2 was decreased(P<0.05),and level of PaO2 was increased(P<0.05);levels of R and PEEPi were decreased(P<0.05),and level of CST was increased(P<0.05).After seven-day treatment,when compared with those in the routine group,levels of CRP and PCT in serum in the combination group were decreased(P<0.05);level of PaCO2 was decreased(P<0.05),and level of PaO2 was increased(P<0.05);levels of R and PEEPi were decreased(P<0.05),an
作者
陈坤
汤玲玲
王丽琼
周良安
CHEN Kun;TANG Lingling;WANG Liqiong;ZHOU Liang’an
出处
《新中医》
CAS
2021年第8期55-58,共4页
New Chinese Medicine
关键词
慢性阻塞性肺疾病急性加重期
呼吸衰竭
补肺益气平喘汤
正压通气
肺功能
Acute exacerbation of chronic obstructive pulmonary disease
Respiratory failure
Bufei Yiqi Pingchuan tang
Positive pressure ventilation
Lung function
