摘要
目的:探讨艾普拉唑联合双歧杆菌三联活菌胶囊对重症急性胰腺炎(SAP)患者疗效及肠道黏膜屏障功能和细胞因子影响。方法:选择2018年6月-2020年6月本院收治的SAP患者98例,依据随机数字表法随机分为观察组49例与对照组49例。观察组给予艾普拉唑联合双歧杆菌三联活菌胶囊治疗,对照组给予双歧杆菌三联活菌胶囊治疗。两组疗程1周。比较两组主要症状和体征恢复时间,以及治疗前与治疗1周血清淀粉酶和脂肪酶、肠道黏膜屏障功能[D-乳酸、二胺氧化酶(DAO)和内毒素]、细胞因子[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和白介素-10(IL-10)]变化。结果:观察组腹痛缓解、肠鸣音恢复和腹胀缓解时间早于对照组(P<0.05)。两组SAP患者治疗1周血清淀粉酶和脂肪酶水平低于治疗前(P<0.05);观察组SAP患者治疗1周血清淀粉酶和脂肪酶水平低于对照组(P<0.05)。两组SAP患者治疗1周血清D-乳酸、DAO和内毒素水平低于治疗前(P<0.05);观察组SAP患者治疗1周血清D-乳酸、DAO和内毒素水平低于对照组(P<0.05)。两组SAP患者治疗1周血清TNF-α和IL-6水平低于治疗前,而IL-10水平高于治疗前(P<0.05);观察组SAP患者治疗1周血清TNF-α和IL-6水平低于对照组,而IL-10水平高于对照组(P<0.05)。结论:艾普拉唑联合双歧杆菌三联活菌胶囊对SAP患者疗效良好,且可改善SAP患者肠道黏膜屏障功能,及减轻SAP患者细胞炎性反应。
Objective:To investigate the effect and intestinal mucosal barrier function and cytokines of Ilaprazole combined with Bifidobacterium Triple Viable Capsules on patients with severe acute pancreatitis(SAP).Method:A total of 98 SAP patients in our hospital from June 2018 to June 2020 were selected and randomly divided into the observation group(49 cases)and the control group(49 cases)according to random number table method.The observation group was given Ilaprazole combined with Bifidobacterium Triple Viable Capsules,while the control group was given Bifidobacterium Triple Viable Capsules.The treatment course of the two groups was 1 week.The recovery time of main symptoms and signs,serum amylase and lipase,intestinal mucosal barrier function[D-lactic acid,diamine oxidase(DAO)and endotoxin],cytokines[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-10(IL-10)]were compared between the two groups before and after 1 week of treatment.Result:The time of abdominal pain relief,bowel sounds recovery and abdominal distension relief in the observation group were earlier than those in the control group(P<0.05).After treatment,the serum amylase and lipase levels in SAP patients of two groups were lower than before treatment(P<0.05);serum amylase and lipase levels in the observation group were lower than those of the control group(P<0.05).After treatment,the serum D-lactic acid,DAO and endotoxin in two groups were lower than before treatment(P<0.05);the serum D-lactic acid,DAO and endotoxin in the observation group were lower than those in the control group(P<0.05).After treatment,the serum TNF-αand IL-6 in SAP patients of two groups were lower than before treatment,and serum IL-10 was higher than before treatment(P<0.05);the serum TNF-αand IL-6 in the observation group were lower than those in the control group,and serum IL-10 was higher than that in the control group(P<0.05).Conclusion:Ilaprazole combined with Bifidobacterium Triple Viable Capsules has a good effect on SAP patients,and can improve the int
作者
胡圣丹
HU Shengdan(Jianli Hospital of Traditional Chinese Medicine,Jianli 433300,China)
出处
《中外医学研究》
2021年第14期8-11,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
