摘要
目的分析血清C肽(CP)、同型半胱氨酸(Hcy)及25-羟维生素D3[25(OH)D3]在糖尿病周围神经病变(DPN)中的变化及意义。方法分析本院内分泌科收治的120例糖尿病患者的临床资料,其中合并DPN者40例(DPN组),未合并DPN者80例(无DPN组),比较两组CP、Hcy、25(OH)D3、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)及神经传导功能情况,分析CP、Hcy、25(OH)D3与其他指标的相关性,并采用多元Logistic回归分析影响糖尿病患者并发DPN的危险因素。结果DPN组CP、25(OH)D3水平显著低于无DPN组,Hcy、FPG、TC及TG显著高于无DPN组,正中神经和胫后神经传导速度均慢于无DPN组,差异均具有统计学意义(P<0.05)。相关性分析显示:DPN患者的Hcy水平与FPG、TC、TG呈正相关(P<0.05),与神经传导速度均呈负相关(P<0.05);而CP、25(OH)D3水平与FPG、TC、TG呈负相关(P<0.05),与神经传导速度均呈正相关(P<0.05)。经logistic回归模型分析,病程、CP、25(OH)D3水平降低及Hcy升高是影响糖尿病患者并发DPN的危险因素(P<0.05)。结论DPN患者存在CP、Hcy及25(OH)D3水平的异常表达,维持机体的CP、Hcy及25(OH)D3水平,有助于延缓DPN的发生、发展。
Objective To analyze the changes and significance of serum C peptide(CP),homocysteine(Hcy)and 25-hydroxyvitamin D3[25(OH)D3]in diabetic peripheral neuropathy(DPN).Methods The clinical data of 120 patients with diabetes admitted to the Department of Endocrinology in our hospital was retrospectively analyzed,including 40 patients with DPN(DPN group)and 80 patients without DPN(nonDPN group).The two groups were compared with CP,Hcy,25(OH)D3,Fasting blood glucose(FPG),Total cholesterol(TC),Triacylglycerol(TG)and nerve conduction function.The correlation between CP,Hcy,25(OH)D3 and other indicators was analyzed.Multivariate Logistic regression analysis was used to analyze the risk factors that affect diabetic patients with DPN.Results The levels of CP and 25(OH)D3 in the DPN group were significantly lower than those in the non-DPN group,and Hcy,FPG,TC and TG were significantly higher than those in the non-DPN group(P<0.05).The conduction velocity of the median nerve and posterior tibial nerve was slower than that of the non-DPN group,and the differences were statistically significant(P<0.05).Correlation analysis showed that Hcy level in DPN patients was positively correlated with FPG,TC,and TG(P<0.05),and negatively correlated with nerve conduction velocity(P<0.05).The levels of CP and 25(OH)D3 were negatively correlated with FPG,TC,and TG(P<0.05),and positively correlated with nerve conduction velocity(P<0.05).According to logistic regression model analysis,the course of disease,the decrease of CP and 25(OH)D3 levels,and the increase of Hcy are the risk factors that affect the occurrence of DPN in diabetic patients(P<0.05).Conclusion DPN patients have abnormal expressions of CP,Hcy and 25(OH)D3 levels.Maintaining the body’s CP,Hcy and 25(OH)D3 levels helps delay the occurrence and development of DPN.
作者
汤步阳
黄莹芝
胡恒贵
刘珍
TANG Buyang;HUANG Yingzhi;HU Henggui;LIU Zhen(Department of Endocrinology,Wanbei Coal Power Group General Hospital,Suzhou,Anhui,China,234000)
出处
《分子诊断与治疗杂志》
2021年第5期816-819,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽省自然科学基金资助项目(1708085MC13)。
