摘要
目的探讨颈总动脉位置处不同狭窄程度对颈动脉内血液流速、血管壁面压力、剪切应力的影响,分析颈总动脉位置处狭窄对脑部供血影响的血流动力学方面原因。方法采用内蒙古民族大学附属医院提供的1例53岁男性健康颈动脉二维CT数据,应用医学建模软件MIMICS20.0将二维CT数据进行三维医学重建,然后利用3-Matic Medical软件,在颈总动脉位置处进行25%、50%、75%狭窄程度的人为干预,得到颈总动脉位置处3种不同程度狭窄的颈动脉模型。在GEOMAGIC中进行模型的光滑处理,经过网格划分及边界条件设置后导入计算流体力学软件FLUENT14.5中,进行液(血浆)—固(红细胞)两相流血流动力学数值模拟。通过观察不同狭窄程度下速度流线图及矢量图(分别截取狭窄处、分叉处上游、分叉处下游及分叉末端处的a、b、c、d 4个不同的横断面)中的血液流速及血液的涡旋流动现象、血管壁面压力及剪切应力的数值变化,为颈动脉狭窄疾病提供血流动力学支持。结果观察速度流线图及速度矢量图可知,从颈动脉入口处流入血液保持狭窄处血管中间流速大、边缘流速小的特点,颈动脉窦处易存在血液的涡旋流动,且随着狭窄程度的增加,涡旋的面积及程度增大。在所取的4个横断面上,随着狭窄程度的增大,涡旋现象持续时间更长。颈总动脉狭窄自25%到50%过程中,血液流速、血管壁面压力及剪切应力扩大至近2倍;当狭窄程度由50%至75%过程中,血液流速扩大至3倍,血管壁面压力扩大至近10倍,剪切应力扩大至近4倍。结论人为狭窄干预技术可以方便、快捷地获取目标模型,并可以在此基础上任意修改,可以为血流动力学研究及临床诊断提供良好的模型基础。颈总动脉狭窄程度由25%到50%时,血管壁面的力学性质发生一定变化;而从狭窄50%到狭窄75%时,血管壁面的力学性质呈指数形式上升。
Objective To investigate the effect of different stenosis degree of common carotid artery on blood flow velocity,vascular wall pressure and shear stress in carotid artery.Also,to analyze hemodynamic reasons of the effect of common carotid artery stenosis on cerebral blood supply.Methods CT data of a 53-year-old male patient provided by the Affiliated Hospital of Inner Mongolia University for Nationalities were used to reconstruct the 3D medical data by the medical modeling software MIMICS20.0.Then 3-Matic Medical software was used to reconstruct three carotid artery models with different degree of carotid artery stenosis by artificial intervention of 25%,50% and 75% stenosis at the position of the common carotid artery.After the smoothing of the model in GEOMAGIC,it was introduced into the computational fluid dynamics software FLUENT14.5 after mesh division and boundary conditions setting.The liquid(plasma)-solid(red blood cell)two-phase bleeding flow dynamics numerical simulation was carried out.The eddy flow of blood,changes of vascular wall pressure and shear stress in the velocity flow diagram(4 different cross sections were taken)under different stenosis degree were observed to provide hemodynamic support for carotid artery stenosis.Results From velocity flow diagram and vector diagram,blood flow from the entrance of carotid artery maintained high flow velocity in the middle and slow flow velocity at the edge of stenotic vascular.Blood vortex flow was easily formed in the carotid sinus,and the area and degree of the vortex increased with the increase of stenosis degree.It was also found duration of the eddy phenomenon was longer with the increase of stenosis degree in four selected cross-sections.During stenosis process from 25% to 50% of common carotid artery stenosis,blood flow velocity,vascular wall pressure and shear stress doubled.When stenosis degree increased from 50% to 75%,blood flow velocity increased to 3 times,pressure on vascular wall increased to about 10 times,and shear stress increased to abo
作者
陈阳
彭红梅
张东威
赵洪明
张红娜
Chen Yang;Peng Hongmei;Zhang Dongwei;Zhao Hongming;Zhang Hongna(College of Mathematics and Physics,Inner Mongolia University for Nationalities,Tongliao,the Inner Mongolia Autonomous Region 028043,China)
出处
《中国脑血管病杂志》
CAS
CSCD
北大核心
2021年第5期296-302,共7页
Chinese Journal of Cerebrovascular Diseases
基金
国家自然科学基金项目(11362015、82060816)
内蒙古自治区自然科学基金项目(2013MS0113、2018LH01005)。
关键词
颈总动脉狭窄
医学模型三维重建
人为狭窄干预技术
两相流动
计算流体力学
Common carotid artery stenosis
Three-dimensional reconstruction of medical models
Artificial intervention of stenosis
Two-phase flow
Computational fluid dynamics
