摘要
目的 颈动脉狭窄程度对动脉粥样硬化斑块的形成机制血流动力学因素分析。方法 采集颈动脉狭窄患者CTA影像数据,应用MIMICS软件创建三种颈动脉狭窄模型(0度狭窄、轻度狭窄、重度狭窄),利用3-matic软件对三种不同狭窄的颈动脉模型进行修复、优化表面网格,利用血流动力学仿真软件SimVascular对三种狭窄率模型进行非牛顿流体数值模拟。结果 颈动脉狭窄区域的血流速度分布与狭窄率紧密联系,狭窄区域壁切应力随着狭窄率增高而变大,狭窄区域壁面压力出现负压,颈动脉狭窄部位壁面切应力随狭窄率增高,血流出现涡流、二次流、回流。结论 狭窄率与颈动脉血流动力学因素密切相关,狭窄率的大小与粥样硬化斑块的形成、发展密切相关。
Objective To analyze the hemodynamic factors impacting the formation mechanism of atherosclerotic plaques by the degree of carotid stenosis. Methods CTA image data of patients with carotid stenosis were collected. 3 types of carotid stenosis models(0-degree stenosis, mild stenosis and severe stenosis) were created by MIMICS software. 3 types of carotid models with different stenosis were repaired and their surface meshes were optimized by 3-matic software. The non-Newtonian fluid numerical simulation of 3 types of stenosis rate models was carried out by the hemodynamic simulation software SimVascular. Results The distribution of blood flow velocity in the carotid stenosis area was closely related to the stenosis rate. The wall shear stress in the narrow area increased with the increase in stenosis rate, and the wall pressure in the narrow area appeared negative pressure. And the wall shear stress in the carotid stenosis area increased with the stenosis rate, resulting in vortex, secondary flow and reflux of blood flow. Conclusion The stenosis rate is closely related to the hemodynamic factors of carotid, and the size of stenosis rate is closely related to the formation and development of atherosclerotic plaque.
作者
高铭泽
陈广新
陈晓琴
胡明成
成志国
林强
GAO Mingze;CHEN Guangxin;CHEN Xiaoqin;HU Mingcheng;CHENG Zhiguo;LIN Qiang(College of Medical Imaging,Mudanjiang Medical University,Heilongjiang,Mudanjiang 157011,China;Hongqi Hospital Affiliated to Mudanjiang Medical University,Heilongjiang,Mudanjiang 157011,China)
出处
《中国医药科学》
2022年第15期46-49,共4页
China Medicine And Pharmacy
基金
黑龙江省省属高等学校基本科研业务费科研项目(2020-KYYWFMY-0047)。
