期刊文献+

气道不同部位一氧化氮测定在慢性阻塞性肺疾病中的价值 被引量:8

The value of exhaled nitric oxide in different parts of the airway in chronic obstructive pulmonary dis⁃ease
下载PDF
导出
摘要 目的探讨气道不同部位呼出气一氧化氮(FeNO)检测在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)中的应用价值。方法选取从2019年1月至2020年5月就诊我院的COPD患者82例进行观察研究。其中COPD稳定期患者37例,COPD急性加重期患者45例,并选取20例健康体检者作为对照组。测定各组呼出气一氧化氮(NO)浓度,记录中心大气道NO浓度(FeNO50)及肺泡NO浓度(CaNO)。同时收集肺功能,血白细胞(WBC),嗜酸性粒细胞百分比(EOS%),C反应蛋白(CRP)和CAT评分等临床变量作为观察指标。结果COPD急性加重组CaNO、CRP、WBC明显高于COPD稳定组及对照组,差异有统计学意义(P<0.05)。在COPD急性加重组,CaNO与CAT评分呈正相关(r=0.627,P<0.001),与FEV1%呈负相关(r=-0.457,P=0.002),而FeNO50与CAT评分及FEV1%无相关性。分层分析发现CaNO在CAT评分>20分及FEV1%<50%组中明显升高(P<0.05),而FeNO50在两组中差异无统计学意义(P>0.05)。结论COPD患者气道不同部位NO浓度存在差异,CaNO可能是反映COPD患者远端小气道炎症更好的生物学指标,可用于监测COPD急性加重期间的炎症活动。 Objective To investigate the value of detecting fractional exhaled nitric oxide(FeNO)in different parts of the airway in chronic obstructive pulmonary disease(COPD).Methods A total of 82 COPD patients admitted to our hospital from January 2019 to May 2020 were selected for an observational study.Among them,37 patients with stable COPD and 45 patients with acute exacerbation of COPD were selected,while 20 healthy subjects were selected as the control group.The exhaled nitric oxide(NO)concentration in each group was determined,and the concentration of NO in central airway(FeNO50)and alveolar NO(CaNO)were recorded.Clinical variables such as lung function,white blood cell count(WBC),eosinophil percentage(EOS%),C⁃reactive protein(CRP)and CAT score were collected as the observation indexes.Results CaNO,CRP and WBC in acute exacerbation of COPD were significantly higher than those in COPD stable group and control group,and the difference was statistically significant(P<0.05).There was a significant positive correlation between CaNO and CAT score(r=0.627,P<0.001)and a significant negative correlation between CaNO and FEV1%(r=-0.457,P=0.002)in COPD with acute exacerbation,while FeNO50 was not significantly correlated with CAT score and FEV1%.Stratified analysis showed that CaNO was significantly increased in CAT score>20 and FEV1%<50%groups(P<0.05),but there was no difference in FeNO50 between the two groups(P>0.05).Conclusion The concentration of NO in different parts of the airway was different in COPD patients.CaNO may be a better biological indicator of small airway inflammation in patients with COPD and can be used to monitor inflammatory activity during acute exacerbation of COPD.
作者 吴敏 金蒙蒙 赵磊 WU min;JIN Mengmeng;ZHAO Lei(Department of Respiratory and Critical Care Medicine,the Fouth Affili-ated Hospital of Anhui Medical University,Hefei 230061,China)
出处 《实用医学杂志》 CAS 北大核心 2021年第9期1145-1149,共5页 The Journal of Practical Medicine
基金 安徽高校省级自然科学研究重点项目(编号:KJ2019A0269) 安徽医科大学校科研基金项目(编号:2018xkj059)。
关键词 呼出气一氧化氮 慢性阻塞性肺疾病 气道炎症 CaNO fractional exhaled nitric oxide chronic obstructive pulmonary disease airway inflamma⁃tion alveolar nitric oxide
  • 相关文献

参考文献1

二级参考文献3

共引文献22

同被引文献62

引证文献8

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部