摘要
慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)是以持续不可逆的气流受限为特征的慢性气道炎症性疾病,而小气道病变是其发展的最早阶段,且与随后出现的气流受限密切相关。现有研究发现,早期小气道病变经治疗后气流受限可逆转,提示若可准确识别早期小气道病变并予以干预,或可改变疾病结局。本文主要从功能性、生物性及影像学三个方面对近年来探索发现的小气道病变检测技术进行综述,以期日后研究可从中找寻小气道病变治疗靶点,从而改善患者预后。
Chronic obstructive pulmonary disease is a chronic airway inflammatory disease characterized by persistent and irreversible airflow limitation,and small airway disease is the earliest stage of its development and is closely related to the subsequent airflow limitation.Existing studies have found that airflow limitation in early-stage small airway lesions can be reversed after treatment,suggesting that if early-stage small airway lesions can be accurately identified and intervened,disease outcomes may be changed.This article mainly reviews the detection technologies of small airway lesions discovered in recent years from three aspects:functional,biological and imaging,in order to find the therapeutic targets for small airway lesions in future research,so as to improve the prognosis of patients.
作者
叶蕾
周建荣
YE Lei;ZHOU Jian-rong(Gannan Medical University;Department of Respiratory Medicine,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000)
出处
《赣南医学院学报》
2022年第4期437-442,共6页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
慢性阻塞性肺疾病
小气道病变
研究进展
Chronic obstructive pulmonary disease
Small airway disease
Research progress
