摘要
目的:观察三仁汤加减联合经验方保留灌肠在湿热型溃疡性结肠炎治疗中的临床疗效。方法:将90例患者按随机数字表法随机分为治疗组和对照组。治疗组采用三仁汤加减口服联合经验方保留灌肠,对照组采用柳氮磺吡啶栓塞肛治疗,各组均予美沙拉嗪肠溶片口服,4周后(28d)观察治疗效果。结果:治疗组治疗前中医症候总积分17.3±4.3,治疗后总积分7.3±2.6;对照组治疗前中医症候总积分16.9±5.2,治疗后总积分9.4±3.1,两组治疗后积分比较,经t检验,P<0.05,差异具有统计学意义,提示治疗组优于对照组;治疗组中医症候疗效总有效率为93.3%,对照组总有效率为82.2%,治疗组明显优于对照组;治疗组内镜疗效总有效率91.1%,对照组内镜疗效总有效率77.8%,治疗组明显优于对照组;治疗组复发率12.5%,对照组复发率33.3%,治疗组复发率明显低于对照组;两组治疗期间均无不良反应,安全性良好。结论:三仁汤加减口服联合经验方保留灌肠是治疗湿热型溃疡性结肠炎的有效方法之一,疗效确切,复发率低,值得临床临床推广应用。
Objective:To explore the clinical efficacy of the treatment on ulcerative colitis by oral Modified Sanren Decoction combined with Empirical Recipe Enema.Methods:90 patients were randomly divided into a treatment group(Modified Sanren Decoction combined with Empirical Recipe enema)and a controlled group(Sulfasalazine Suppositories),each group was given Mesalazine Enteric-coated Tablets orally.The therapeutic effect was observed 4 weeks later(28 days).Results:In the observation group,the TCM symptoms total score of prior treatment was 17.3±4.3,the total score of post-treatment was 7.3±2.6;the total scores of TCM symptoms before treatment and after treatment in the controlled group were 16.9±5.2 and 9.4±3.1,respectively.Comparison of scores after treatment between the two groups was performed by T-test,the difference was statistically significant,suggesting that the treatment group was superior to the controlled group.With respect to the total curative effect of TCM symptoms,the observation group(93.3%)was obviously better than the controlled groups(82.2%).The total effective rate of endoscopic efficacy in the observation group was 91.1%,and that in the controlled group was 77.8%.The observation group was significantly better than the controlled groups.The recurrence rate in the observation group was 12.5%,and that in the controlled group was 33.3%,the observation group was significantly lower than that in the controlled group.Conclusion:Modified Sanren Decoction oral administration combined with Empirical Recipe retention enema is effective for ulcerative colitis with heat-dampness,also with low recurrence rate,which is worthy of clinical promotion and application.
作者
周屹
彭勇
贺平
肖小龙
ZHOU Yi;PENG Yong;HE Ping(Chengrdu Anoretal Special Hospital,Chengdu Sichuan 610031,China)
出处
《四川中医》
2021年第4期114-118,共5页
Journal of Sichuan of Traditional Chinese Medicine
关键词
湿热型
溃疡性结肠炎
三仁汤加减
保留灌肠
临床观察
Heat-dampness
Ulcerative colitis
Modified Sanren Decoction
Retention enema
Clinical observation
