摘要
目的观察三仁汤加减口服对急性发作期溃疡性结肠炎(湿热证)的临床疗效以及炎症因子的影响。方法选取溃疡性结肠炎(湿热证)急性发作期患者60例,按随机数字表法分为对照组及试验组各30例。对照组予以美沙拉嗪片口服,试验组在对照组基础上予三仁汤加减口服,两组均连续服用2周。观察两组治疗前后临床症状积分、炎症因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]、结肠镜检查结果,对结肠镜评分、黏膜组织评分、Mayo指数评分以及临床疗效进行评估。结果治疗2周后,两组患者腹痛、腹泻、腹胀、里急后重、脓血便、肛门灼热感评分均降低(P<0.05),且试验组患者治疗后积分低于对照组(P<0.05);两组治疗后结肠镜评分、黏膜组织评分、Mayo指数评分均降低,且试验组明显低于对照组(P<0.05);两组患者治疗后IL-6、IL-8、TNF-α均降低,且试验组低于对照组(P<0.05);试验组总有效率为86.67%,高于对照组的73.33%(P<0.05)。结论三仁汤加减口服治疗溃疡性结肠炎(湿热证)急性发作期患者有着较好的临床疗效,可改善患者临床症状,降低结肠镜评分、黏膜组织评分、Mayo指数评分,并减轻炎症反应。
Objective:To observe the clinical efficacy of modified Sanren Decoction on patients with acute attack of damp-heat type ulcerative colitis and its effect on inflammatory factors.Methods:A total of 60 patients with acute attack of damp-heat type ulcerative colitis were randomly divided into the control group and experimental group;the control group was given mesalazine tablets orally,while the experimental group was given modified Sanren Decoction on the basis of the control group.Both groups were treated continuously for 2 weeks.The clinical symptom score,inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)]were observed before and after treatment.Colonoscopy was performed to evaluate the changes of colonoscopy score,mucosal tissue score,Mayo index score and clinical curative effect.Results:After 2 weeks of treatment.1)the scores of abdominal pain,diarrhea,abdominal distension,urgency,purulent bloody stool and anal burning sensation in the two groups were significantly lower(P<0.05),and the scores of patients in the experimental group after treatment were lower than those in the control group,the difference was statistically significant(P<0.05);2)after treatment,the scores of colonoscopy,mucosal tissue and Mayo index in the two groups decreased,and the scores in the experimental group were significantly lower than those in the control group,the difference was statistically significant(P<0.05);3)the levels of IL-6,IL-8 and TNF-αin the two groups after treatment were decreased,and the levels in the experimental group were significantly lower than those in the control group,the difference was statistically significant(P<0.05);4)the total clinical effective rate was 86.67%in the experimental group and 73.33%in the control group,and the difference was statistically significant(P<0.05).Conclusion:Sanren Decoction has a good clinical efficacy in the treatment of patients with acute attack of damp-heat type ulcerative colitis.It can improve patients′clinical symptoms,reduce
作者
柴小琴
冯文哲
雷彪
牛魁
石鹏
Chai Xiaoqin;Feng Wenzhe;Lei Biao;Niu Kui;Shi Peng(The Affiliated Hospital of Shaarwci University of Chinese Medicine,Shaanxi,Xianyang 712000,China)
出处
《中国中医急症》
2022年第3期381-383,398,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
国家自然科学基金项目(81973865)。
关键词
溃疡性结肠炎
急性期
湿热型
三仁汤
美沙拉嗪肠溶片
Ulcerative colitis
Acute period
Damp-heat type
Sanren Decoction
Mesalazine enteric-coated tablets
