摘要
The abnormal regulation of alternative splicing is usually accompanied by the occurrence and development of tumors,which would produce multiple different isoforms and diversify protein expression.The aim of the present study was to conduct a systematic review in order to describe the regulatory mechanisms of alternative splicing,as well as its functions in tumor cells,from proliferation and apoptosis to invasion and metastasis,and from angiogenesis to metabolism.The abnormal splicing events contributed to tumor progression as oncogenic drivers and/or bystander factors.The alterations in splicing factors detected in tumors and other mis-splicing events(i.e.,long non-coding and circular RNAs)in tumorigenesis were also included.The findings of recent therapeutic approaches targeting splicing catalysis and splicing regulatory proteins to modulate pathogenically spliced events(including tumor-specific neo-antigens for cancer immunotherapy)were introduced.The emerging RNA-based strategies for the treatment of cancer with abnormally alternative splicing isoforms were also discussed.However,further studies are still required to address the association between alternative splicing and cancer in more detail.
基金
supported by National Key Research and Development Program:Precision Medicine sub-program 2016YFC0905900(to YY)
National Natural Science Foundation of China 81970196 and 81670200(to C.G.&Y.Y.)
A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(Integration of Chinese and Western Medicine)
Innovation Team of Six Talent Peaks Project in Jiangsu Province(TD-SWYY-015)
Natural Science Foundation of Jiangsu Province for Excellent Young Scholars.
