摘要
炎症性肠病(inflammatory bowel disease,IBD)是以辅助性T细胞分化和功能紊乱为免疫病理特征,涉及单核吞噬细胞亚群在内的多细胞网络和复杂细胞因子网络的自身免疫性疾病。目前炎症性肠病的疗法多定靶一个或几个因素,非系统性的治疗常常加重疾病的严重性和复杂性。‘蠕虫疗法’能够通过系统性地调节固有性免疫应答,影响巨噬细胞和树突状细胞的亚型和功能,发挥免疫调节和免疫抑制作用,在炎症性肠病中表现出良好的治疗潜能。
Inflammatory bowel disease(IBD)is a type of autoimmune disease characterized by the disrupted differentiation and function of T helper cells,and IBD involves complex cytokine networks and multi-cell networks that include mononuclear phagocytes.At present,the treatment of IBD mainly targets one or a few factors,and this form of treatment is not systemic,so it may exacerbate the severity or complexity of the disease.‘Helminth therapy’has the potential to treat IBD by regulating the innate immune response systematically,influencing the subtypes and functions of macrophages and dendritic cells and causing immunoregulation and immunosuppression.
作者
渠铮
张媛媛
金雪敏
白雪
刘晓雷
刘明远
QU Zheng;ZHANG Yuan-yuan;JIN Xue-min;BAI Xue;LIU Xiao-lei;LIU Ming-yuan(Key Laboratory of Zoonosis Research,Ministry of Education,Institute of Zoonosis,College of Veterinary Medicine,Jilin University,Changchun 130062,China)
出处
《中国病原生物学杂志》
CSCD
北大核心
2021年第2期245-248,F0003,F0004,共6页
Journal of Pathogen Biology
基金
国家重点研发计划项目(No.2017YFC1601200)
国家自然科学基金重点项目(No.31520103916)。
关键词
炎症性肠病
蠕虫疗法
巨噬细胞
树突状细胞
免疫调节
免疫抑制
综述
inflammatory bowel disease
helminth therapy
macrophage
dendritic cell
immunoregulation
immunosuppression
review
