摘要
作为一种炎性肠病,溃疡性结肠炎(ulcerative colitis,UC)的发病机制尚未被完全揭示,其治疗策略仍需继续探索。动物模型是疾病研究中不可或缺的工具。因此,建立与人类UC发病机制、病理表现类似的动物模型有利于对该疾病进行充分研究。本文梳理了UC动物模型的研究进展,发现化学药物诱导是迄今为止最常用的UC造模方法;基于基因组学技术的发展,基因编辑或基因敲除诱导的自发性结肠炎则是未来动物模型研究的重要方向;评价UC动物模型造模结果的指标仍需进一步探索。
Ulcerative colitis(UC)is a chronic,idiopathic inflammatory bowel disease.Its pathogenesis has not been fully revealed.Moreover,the lack of effective and safe treatment strategies is an obstacle for UC treatment currently.Animal models are essential tools in disease research.Therefore,the establishment of animal models with pathological manifestations similar to human UC is conducive to the full study of this disease.In this review,we reviewed the research progress of animal models of UC,and found that chemical induction is the most commonly used method for modeling UC.Based on the development of genomics technology,gene editing or knockout-induced spontaneous colitis is a vital direction for animal models research in the future.In addition,the indexes for evaluating the modeling results of UC animal models need to be further explored.
作者
胡宇
兰昀羲
陈晓晓
熊伟
唐宋琪
贾波
黄巍
HU Yu;LAN Yunxi;CHEN Xiaoxiao;XIONG Wei;TANG Songqi;JIA Bo;HUANG Wei(Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Chengdu Qihuang Boen Bio-technology Co.,Ltd.,Chengdu 611139,China;Hainan Medical University,Haikou 571199,China)
出处
《实验动物与比较医学》
CAS
2022年第3期220-228,共9页
Laboratory Animal and Comparative Medicine
基金
国家自然科学基金资助项目:基于异功散中陈皮对肠吸收动力学影响的“补而不滞”配伍机制研究(81860816)
国家自然科学基金资助项目:逆流挽舟法调控tuft细胞促肠干细胞增殖修复溃疡性结肠炎黏膜的机制研究(82074327)。
关键词
溃疡性结肠炎
动物模型
发病机制
基因敲除
评价指标
Ulcerative colitis
Animal model
Pathogenesis
Gene knockout
Evaluation Indicators
