摘要
目的:观察紫朱软膏外用治疗非缺血性糖尿病足溃疡的临床疗效。方法:将符合纳入标准的76例糖尿病足溃疡患者随机分为治疗组和对照组,每组38例。治疗组予紫朱软膏外敷治疗,对照组予重组牛碱性成纤维细胞生长因子(贝复济)喷剂联合银离子抗菌喷剂湿敷治疗。两组观察4周,通过对临床截肢率、创面面积、创周皮肤温度、分泌物量、感染性炎症指标白细胞、中性粒细胞、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)等的比较,评价紫朱软膏的临床疗效和作用机制。结果:1.试验组与对照组的患者一般资料分析,在性别、年龄、病程、入组时的溃疡面积经统计物差异(P=0.572,P=0.574,P=795,均>0.05),表明两组治疗前无明显差异,具有可比性。2.两组患者的丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST,U/L)、肌酐(Cr,μmol/L)、尿素氮(BUNμmol/L)、空腹血糖(FPG,mmol/L)、糖化血红蛋白(HbA1c,%)两组比较无明显差异(P=0.968,P=0.861,P=0.860,P=0.967,P=0.069,P=0.230,均>0.05)。表明紫朱软膏具有良好的药物安全性。3.两组截肢率比较无统计学差异(P=0.644>0.05),截肢平面在足踝以下足趾。溃疡面积治疗前两组溃疡面积比较无统计学差异(P=0.244>0.05),表明两组具有可比性,治疗后两组溃疡面积比较具有统计学差异(P=0.022<0.05),试验组溃疡面积小于对照组。治疗前后的溃疡面积差值比较,具有统计学差异(P=0.044<0.05),试验组在改善溃疡面积上优于对照组。4.治疗前后两组皮温比较,前后差值,差异无统计学意义(P=0.379,P=0.188,P=0.632>0.05)。两组患者的创面分泌物量的比较,治疗前两组分泌物量比较,差异无统计学意义(P=0.801>0.05)。治疗后及治疗前后分泌物量差值,具有统计学差异(P=0.001<0.01),(P=0.011<0.05);治疗后试验组创面分泌物量更少,治疗期间促进分泌物释放作用更强。5.试验组与对照组白细胞计数、中性粒细�
Objective: Diabetic foot ulcer was one of the serious complications of diabetes.It seriously reduced the quality of life of diabetic patients and caused a heavy medical burden on patients and the society.It was a difficult clinical problem to be solved urgently.Zizhu Ointment was an effective prescription for diabetic foot ulcers in our hospital.This study aimed to observe the clinical efficacy of Zizhu Ointment for external treatment of non-ischemic diabetic foot ulcers.Methods: 76 patients with diabetic foot ulcers that met the inclusion criteria were randomly divided into a treatment group and a controlled group, 38 cases in each group.The treatment group was treated with Zizhu Ointment, and the controlled group was treated with recombinant bovine basic fibroblast growth factor(Beifuji) spray combined with silver ion antibacterial spray wet compress.The two groups were observed for 4 weeks, through the clinical amputation rate, wound area, wound skin temperature, secretion volume, infectious inflammation indicators white blood cells, neutrophils, interleukin 6(IL-6),tumor necrosis factor-α(TNF-α),etc.,to evaluate the clinical efficacy and mechanism of Zizhu Ointment.Results: 1.Analysis of the general data of the patients in the test group and the controlled group, the statistical difference between the ulcer area at sex, age, course of disease, and enrollment(P=0.572,P=0.574,P=795,all> 0.05).It showed that there is no obvious difference between the two groups before treatment, and they were comparable.2.Alanine aminotransferase(ALT),aspartate aminotransferase(AST,U/L),creatinine(Cr, μmol/L),urea nitrogen(BUN,μmol/L).There was no significant difference in fasting blood glucose(FPG,mmol/L) and glycated hemoglobin(HbA1 c, %) between the two groups(P=0.968,P=0.861,P=0.860,P=0.967,P=0.069,P=0.230,both>0.05).It showed that Zizhu Ointment had good drug safety.3.There was no significant difference in the amputation rate between the two groups(P=0.644>0.05).The amputation plane was below the ankle and toes.There wa
作者
韩强
柳国斌
HAN Qiang;LIU Guobin(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《四川中医》
2021年第3期112-117,共6页
Journal of Sichuan of Traditional Chinese Medicine
基金
国家自然科学基金青年项目(编号:81804095)
上海中医健康服务协同创新中心项目(编号:ZYJKFW201701002)。
关键词
紫朱软膏
糖尿病足溃疡
煨脓长肉
Zizhu Ointment
Diabetic foot ulcer
Removing pus and promoting granulation
