摘要
冠状动脉粥样硬化性心脏病(CHD)简称冠心病,是对人类生命和健康威胁极大的疾病。据统计,全球冠心病年死亡人数超过700万,在235个单病种死因中排首位。据专家预测,未来20年冠心病将持续成为全球死亡的首位原因。ghrelin在心血管系统中的作用不仅通过其生长激素释放作用来介导,而且还通过对心脏的直接作用来介导。生长激素释放肽的外源给药可扩张外周血管,收缩冠状动脉,改善内皮功能,并抑制心肌细胞凋亡。因此,生长激素释放肽可能具有心血管保护作用,包括降低血压,调节动脉粥样硬化,保护免受缺血/再灌注损伤,以及改善心肌梗塞和心力衰竭的预后。
Coronary atherosclerotic heart disease(CHD),referred to as coronary heart disease,is a disease that threatens human life and health.According to statistics,the annual death toll of coronary heart disease in the world exceeds 7 million,ranking the first among 235 single disease death causes.According to experts’prediction,coronary heart disease will continue to be the leading cause of death in the world in the next 20 years.The role of ghrelin in the cardiovascular system is mediated not only by its growth hormone release,but also by its direct effect on the heart.Exogenous administration of ghrelin can dilate peripheral blood vessels,constrict coronary arteries,improve endothelial function and inhibit cardiomyocyte apoptosis.Therefore,ghrelin may have cardiovascular protective effects,including lowering blood pressure,regulating atherosclerosis,protecting against ischemia/reperfusion injury,and improving the prognosis of myocardial infarction and heart failure.
作者
郑龙宇
陆旭
张丽
Zheng Longyu;Lu Xu;Zhang Li(The First Affiliated Hospital of Jiamusi University,Jiamusi 154000,China)
出处
《广东化工》
CAS
2021年第1期126-127,共2页
Guangdong Chemical Industry
