摘要
目的研究溶栓联合丁苯肽氯化钠治疗急性脑梗死的临床效果及对患者认知功能的影响。方法选取2019年10月~2020年10月我院收治的108例急性脑梗死患者作为研究对象,采用随机数字表法分为对照组和观察组,各54例。对照组采用常规溶栓治疗,观察组在对照组基础上给予丁苯肽氯化钠治疗,比较两组治疗效果、NIHSS评分、MMSE评分、Barthel评分及不良反应发生情况。结果观察组治疗总有效率(92.59%)高于对照组(81.48%),差异有统计学意义(P<0.05);治疗后两组NIHSS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后两组MMSE、Barthel评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论溶栓联合丁苯肽氯化钠治疗急性脑梗死疗效确切,可促进患者神经功能恢复,提高其认知功能和日常生活能力,且不会增加不良反应,安全可靠。
Objective To study the clinical effect of thrombolysis combined with Butylphthalide and sodium chloride in the treatment of acute cerebral infarction and its influence on patients'cognitive function.Methods A total of 108 patients with acute cerebral infarction admitted to our hospital from October 2019 to October 2020 were selected as the research objects,and they were divided into the control group and the observation group by random number table method,with 54 cases in each group.The control group was treated with conventional thrombolysis,and the observation group was treated with Butylphthalide and sodium chloride on the basis of the control group.The treatment effect,NIHSS score,MMSE score,Barthel score and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(92.59%)was higher than that in the control group(81.48%),the difference was statistically significant(P<0.05);After treatment,the NIHSS scores of the two groups were lower than those before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);After treatment,the MMSE and Barthel scores of the two groups were higher than those before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05);There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Thrombolysis combined with Butylphthalide and sodium chloride has a definite effect in the treatment of acute cerebral infarction.It can promote the recovery of neurological function of patients,improve their cognitive function and ability of daily living,without increasing adverse reactions,and is safe and reliable.
作者
王楠
WANG Nan(Department of Neurology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
出处
《医学信息》
2021年第10期113-115,共3页
Journal of Medical Information
关键词
丁苯酞氯化钠
急性脑梗死
认知功能
Butylphthalide and sodium chloride
Acute cerebral infarction
Cognitive function
