摘要
目的:探讨丁苯酞氯化钠注射液联合纤溶酶原激活剂(rt-PA)静脉溶栓对4.5 h内急性脑梗死(ACI)患者的治疗作用。方法:以97例4.5 h内ACI患者作为研究对象,随机分为观察组与对照组。对照组给予rt-PA静脉溶栓及常规治疗,观察组在对照组的基础上,加用丁苯酞氯化钠注射液治疗。分析两组疗效、血管内皮功能和不良反应。结果:治疗后,观察组总有效率93.87%,高于对照组72.91%(P<0.05);观察组血管内皮功能改善优于对照组,且治疗期无明显不良反应发生(P<0.05)。结论:丁苯酞氯化钠注射液增强rt-PA静脉溶栓对新近ACI患者的治疗效果,改善血管内皮功能。
Objective:To investigate the therapeutic effect of intravenous thrombolysis of sodium butylphthalide chloride injection combined with recombinant human tissue-type plasminogen activator(rt-PA)on patients with acute cerebral infarction(ACI)within 4.5 h.Methods:A total of 97 patients with onset of ACI within 4.5 h were selected as the research objects and randomized into the observation group and control group.The control group were treated with rt-PA intravenous thrombolysis and conventional treatment,and the observation group were treated with butylphthalide sodium chloride injection on the basis of the control group.Then,the efficacy,vascular endothelial function and adverse reactions were compared between the two groups.Results:After treatment,the total effective rate of the observation group was 93.87%,which was higher than 72.91%of the control group(P<0.05);the improvement of vascular endothelial function in the observation group was higher than that of the control group and there was no adverse reactions during the treatment(P<0.05).Conclusion:Butylphthalide and sodium chloride injection can enhance the therapeutic effect of intravenous rt-PA thrombolysis in patients with newly acquired ACI and improve the patients’vascular endothelial functions.
作者
李娜
曹雅琼
LI Na;CAO Yaqiong(Stroke Center,the People’s Hospital of Hebi,Hebi 458030,China)
出处
《华夏医学》
CAS
2021年第1期48-51,共4页
Acta Medicinae Sinica
关键词
丁苯酞氯化钠
急性脑梗死
血管内皮功能
纤溶酶原激活剂
一氧化氮
butylphthalide sodium chloride
acute cerebral infarction(ACI)
vascular endothelial function
recombinant human tissue-type plasminogen activator(rt-PA)
nitric oxide
