摘要
目的观察正电子发射计算机断层显像/计算机断层扫描(PET/CT)联合血清癌胚抗原(CEA)、YKL-40对卵巢癌的诊断价值。方法选取我院96例超声检查发现卵巢肿块患者,均接受PET/CT检查与血清CEA、YKL-40检测,以病理诊断为"金标准",分为卵巢癌组与良性肿瘤组,另取同期50例体检健康妇女为对照组,比较3组血清CEA与YKL-40水平、卵巢癌组与良性肿瘤组最大标准摄取值(SUVmax),并分析PET/CT、CEA、YKL-40及三者联合对卵巢癌诊断价值。结果血清CEA水平为:卵巢癌组>良性肿瘤组>对照组,比较差异显著(P<0.05);卵巢癌组血清YKL-40水平明显高于良性肿瘤组与对照组(P<0.05),良性肿瘤组与对照组比较无显著差异(P>0.05);卵巢癌组SUVmax显著高于良性肿瘤组(P<0.05);PET/CT诊断灵敏度82.26%,特异度76.47%,准确性80.21%,Kappa值0.58;CEA诊断灵敏度77.42%,特异度67.65%,准确性73.96%,Kappa值0.44;YKL-40诊断灵敏度75.81%,特异度85.29%,准确性79.17%,Kappa值0.57;三者联合诊断灵敏度96.77%,特异度91.18%,准确性94.79%,Kappa值0.89;三者联合对卵巢癌诊断灵敏度、准确性明显高于PET/CT、CEA、YKL-40单项检查(P<0.05),特异度明显高于CEA(P<0.05)。结论 PET/CT联合血清CEA、YKL-40检查可有效提高卵巢癌诊断灵敏度与准确性,具有重要应用价值。
Objective To observe the diagnostic value of positron emission tomography/computer tomography(PET/CT)combined with serum carcinoembryonic antigen(CEA)and YKL-40 in ovarian cancer.Methods Ninety-six patients with ovarian masses found in ultrasound examination were selected and su bjected to PET/CT and serum CEA and YKL-40 testing.Pathological diagnosis was to ken as the golden standard according to which the patients were divided into ovarian cancer and benign tumor groups.Meanwhile,50 healthy women were selected as the control group.Serum CEA and YKL-40 levels in the 3 groups were compared.The maximum standardized uptake value(SUVmax)was compared between the ovarian cancer group and the benign tumor group.Value of PET/CT,CEA,YKL-40,and the combination of the three in the diagnosis of ova rian ca ncer was analyzed.Results Serum CEA level was the highest in the ovarian cancer group,followed by the benign tumor group,and the lowest in the control group(P<0.05).Serum YKL-40 level of ovarian cancer group was significantly higher than that of benign tumor group or control group(P<0.05),but there was no significa nt difference between the benign tumor group and the control group(P>0.05).The SUVmax of the ovarian cancer group was significantly higher than that of the benign tumor group(P<0.05).The diagnostic sensitivity,specificity,accuracy and Kappa value of PET/CT were 82.26%,76.47%,80.21%,and 0.58,which of CEA were77.42%,67.65%,73.96%,and 0.44,of YKL-40 were 75.81%,85.29%,79.17%,and 0.57.The combined diagnostic sensitivity,specificity,accuracy and Kappa value of the three were 96.77%,91.18%,94.79%,and 0.89.The sensitivity and accuracy of the combination of the three were significantly higher than PET/CT,CEA,or YKL-40 single diagnosis(P<0.05).The specificity was significantly higher than CEA(P<0.05).Conclusion PET/CT combined with serum CEA and YKL-40 can effectively improve the sensitivity and accuracy in diagnosing ova rian cancer.
作者
徐新胜
XU Xin-sheng(Department of Imaging,Kaifeng Cancer Hospital,kaifeng 475300,henan province,china)
出处
《中国CT和MRI杂志》
2021年第6期137-140,共4页
Chinese Journal of CT and MRI
