摘要
动脉粥样硬化(atherosclerosis,AS)是一种以脂质沉积血管为主的慢性疾病,越来越多研究认为免疫介导的炎症反应在AS的发病机制中有着重要的作用。Toll样受体4(toll-like receptor4,TLR4)作为天然免疫模式识别受体家族中的一员,参与AS的发病各个阶段,因此成为了治疗AS的一个重要靶点。本文就TLR4与AS相关研究进展作一综述。
Atherosclerosis(AS)is a chronic disease characterized by lipid deposits in blood vessels.An increasing number of studies suggest that immune-mediated inflammatory responses play an important role in the pathogenesis of AS.Toll-like receptor 4(TLR4)participates in various stages of AS as a member of the natural immune pattern recognition receptor family,and thus has become an important target for the treatment of AS.This article reviews the progress in research regarding TLR4 and AS.
作者
李嘉慧
王欣佩
冷静
LI Jiahui;WANG Xinpei;LENG Jing(Department of Immunology,Basic Medical College of Guangxi Medical University,Nanning 530000,China;Guangxi University of Chinese Medicine,Guangxi Key Laboratory of Translational Medicine for Treating High-Incidence Infectious Diseases with Integrative Medicine,Nanning 530200;Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences and Comparative Medicine Center,Peking Union Medical College,Beijing 100021)
出处
《中国比较医学杂志》
CAS
北大核心
2021年第4期137-142,共6页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(31460243)。
