摘要
目的:研究灯盏乙素对大鼠实验性动脉粥样硬化的防治作用。方法:复制免疫损伤加高脂喂养大鼠AS模型,观测灯盏乙素对大鼠血清SOD、NO、MDA、血脂、tP A和PAI-1水平及主动脉病变的影响。结果:10、20 mg/kg的灯盏乙素明显升高血清SOD和NO水平,降低血清MDA水平;明显降低TG、TC和LDL-C水平,同时升高HDL-C水平;能明显降低血清PAI-1水平,同时升高血清tP A水平;并可减轻主动脉病变。结论:灯盏乙素体内具有抗氧化、改善血脂异常、维持纤溶系统平衡和减轻主动脉病变的作用。
Objective： To investigate the preventional effect of Seutellarin on experimental atherosclerosis in rats. Methods： The atherosclerotic model of high fatty diet combined with immunologic injury in rats was duplicated to evaluate the effect of scutellarin on the levels of superoxide dismutase （SOD） , nitric oxide （NO） , malondialdehyde （MDA） , blood lipid, tissue type plasminogen activator （tPA） , plasminogen activa- tor inhibitor-1 （PAI-1） and the lesions of aorta. Results： Seutellarin of 10 and 20 mg/kg obviously increased the serum SOD, NO, HDL-C and tPA levels while decreased the serum MDA, TG, TC and PAl-1 levels. Conclusion： Scutellarin has antioxidation, improves the lipid dis- order, maintains the balance of fibrinolytic system and suppresses the aggravation of aorta in atheroselerotic rats.
出处
《中药药理与临床》
CSCD
北大核心
2017年第2期59-63,共5页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然科学基金项目(No:81260493
81660613)
云南省-昆明医科大学联合基金项目(No:2013FB103)的资助
