摘要
目的研究高脂血症患者血浆致动脉粥样硬化指数与同型半胱氨酸、尿酸等血栓形成危险因子的相关性。方法采用标准方法测定100例高脂血症患者和109例正常血脂对照者血脂及血同型半胱氨酸、尿酸、凝血因子Ⅶ、11-脱氢血栓素B2、6-酮-前列腺素F1α等血栓形成危险因子,根据甘油三酯与高密度脂蛋白胆固醇比值的对数转换值计算血浆致动脉粥样硬化指数值,用多元线性回归分析血浆致动脉粥样硬化指数、同型半胱氨酸、尿酸与其它血栓形成危险因子之间的相关性。结果高脂血症组体质指数、血浆致动脉粥样硬化指数、血糖、低密度脂蛋白胆固醇、凝血因子Ⅶ、6-酮-前列腺素F1α及非高密度脂蛋白胆固醇显著升高(P<0.01),11-脱氢血栓素B2水平显著降低(P<0.01);血浆致动脉粥样硬化指数与体质指数、血糖、甘油三酯、尿酸、非高密度脂蛋白胆固醇、凝血因子Ⅶ及同型半胱氨酸呈正相关(P<0.05),与高密度脂蛋白胆固醇呈负相关(r=-0.726,P<0.01);同型半胱氨酸与年龄、血压、尿酸呈正相关(P<0.01);尿酸与甘油三酯、体质指数及11-脱氢血栓素B2呈正相关(P<0.05或P<0.01);同型半胱氨酸、尿酸及体质指数与高密度脂蛋白胆固醇呈负相关(P<0.01)。结论高脂血症患者血浆致动脉粥样硬化指数、6-酮-前列腺素F1α、非高密度脂蛋白胆固醇和凝血因子FⅦ等显著高于正常血脂对照组,总胆固醇、甘油三酯与多项血栓形成危险因子相关。血浆致动脉粥样硬化指数与肥胖、高血压、同型半胱氨酸,尿酸及血脂参数呈一定相关性,能够更加准确地评估血脂代谢综合征发生的危险度,当血浆致动脉粥样硬化指数升高时,应引起临床重视。
Aim To investigate the correlations of atherogenic index of plasma with serum lipids of hyperlipidaemia patients and their thrombotic risk factors.Methods Serum lipids and homocysteine,uric acid,6-Keto-PGF1,TXB2,FⅦ and other biochemical parameters were detected by standard methods in 100 cases of hyperlipidaemia and 109 controls.The atherogenic index of plasma（AIP）was calculated,and the correlation of AIP,UA,Hcy with other thromboplastic risk factors were analyzed by multiple linear regression respectively.Results Compared to controls,the levels of TC,TG,BMI,AIP,GLU,LDLC,FⅦ,PGI2 and non-HDLC were significantly increased（P〈0.01）,and the levels of TXB2 and TXB2/PGI2 were decreased（P〈0.01）in the hyperlipidaemia.The index of AIP was significantly and positively correlated with BMI,DBP,GLU,TG,UA,non-HDLC,SBP,FⅦ and Hcy and negatively correlated with HDLC（P〈0.05）.Serum homocysteine was significantly and positively correlated with age,SBP,DBP,UA and negatively correlated with HDLC（P〈0.01）.The level of UA was significantly and positively correlated with TG,BMI,TXB2（P〈0.05 or P〈0.01）and negatively correlated with HDLC（P〈0.01）.BMI was positively correlated with TG,DBP,UA（P〈0.01）and negatively correlated with HDLC（P〈0.01）.Conclusion The levels of AIP,PGI2,non-HDLC and FⅦ were significantly increased in hyperlipidaemic patients compared to control subjects.TC and TG were correlated with various thrombotic risk factors.The index of AIP was corresponding closely to BMI,DBP,GLU,TG,UA,non-HDLC,SBP,FⅦ and Hcy.AIP could accurately evaluate the risk of hyperlipidaemia patients,AIP was closely related to homocysteine,high uric acid hematic disease and high level of FⅦ,which formed the atherosclerosis risk factors.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2010年第10期799-802,共4页
Chinese Journal of Arteriosclerosis
基金
浙江省医学卫生科研基金资助(2003B019)
