摘要
目的:探究双歧四联活菌片辅助复方消化酶胶囊治疗小儿厌食症的效果及对胃肠激素的影响。方法:选取2018年3月—2019年9月门诊收治的126例厌食症患儿,通过随机数表分为试验组和常规组,每组63例。常规组服用复方消化酶胶囊,试验组在常规组基础上增加双歧四联活菌片辅助治疗。对比2组患儿治疗前后日摄食量、体质量及血浆血红蛋白(Hb)水平、临床疗效、治疗前后血清胃肠激素[胃动素(MTL)、胃泌素(GAS)、血管活性肠肽(VIP)、生长抑素(SS)]水平、不良反应发生率。结果:治疗前2组患儿日摄食量、体质量及血浆Hb水平,差异无统计学意义(P>0.05)。治疗后2组患儿日摄食量、体质量及血浆Hb平均明显增加(P<0.05),且试验组患儿日摄食量、体质量及血浆Hb水平均高于常规组(P<0.05)。2组临床疗效分布差异有统计学意义(P<0.05),试验组总有效率高于常规组(P<0.05)。治疗前2组血清MTL、GAS、VIP、SS水平差异无统计学意义(P>0.05)。治疗后2组血清MTL、GAS水平均升高(P<0.05),血清VIP、SS水平均降低(P<0.05),且试验组血清MTL、GAS水平均高于常规组(P<0.05),血清VIP、SS水平均低于常规组(P<0.05)。试验组不良反应发生率与常规组差异无统计学意义(P>0.05)。结论:对厌食症患儿采用双歧四联活菌片辅助复方消化酶胶囊进行治疗能增加日摄食量、体质量、血浆Hb水平,还能增强临床疗效、改善胃肠激素水平,且安全性良好。
Objective:To explore the effect of bifido tetragenous viable bacterium tablets adjuvant compound digestive enzyme capsules treatment of pediatric anorexia and its influence on gastrointestinal hormones.Methods:One hundred and twenty six children with pediatric anorexia from outpatient department in our hospital during March 2018 to September 2019 were randomly divided into experimental group and routine group with 63 cases in each group.The routine group was given compound digestive enzyme capsules,while the experimental group was treated with bifido tetragenous viable bacterium tablets on the basis of the routine group.The food intake,daily food intake,body weight,and plasma hemoglobin(Hb)levels before and after treatment,clinical effect,as well as serum gastrointestinal hormone(motilin[MTL],gastrin[GAS],vasoactive intestinal peptide[VIP],somatostatin[SS])levels before and after treatment,and the incidence of adverse reactions were compared in the two groups.Results:There was no statistical difference in the daily food intake,body weight,and plasma Hb levels of the two groups before treatment(P>0.05).After treatment,the daily food intake,body weight,and plasma Hb levels of the two groups were significantly increased(P<0.05),and the daily food intake,body weight,and plasma Hb levels of the experimental group were higher than that of the routine group(P<0.05).There was a statistically significant difference in the distribution of clinical effect between the two groups(P<0.05),and the total effective rates of the experimental group was higher than that of the routine group(P<0.05).There was no statistical difference in the serum MTL,GAS,VIP and SS levels in the two groups before treatment(P>0.05).After treatment,the levels of serum MTL and GAS were all increased(P<0.05),the levels of serum VIP and SS were decreased(P<0.05).There was no significant difference in the incidence of adverse reactions between the experimental group and the routine group(P>0.05).Conclusion:Bifido tetragenous viable bacterium tablets combi
作者
巩露
赵琳琳
封东进
GONG Lu;ZHAO Linlin;FENG Dongjin(Department of Gastroenterology,Xuzhou Children's Hospital,Xuzhou,221000,China)
出处
《中国中西医结合消化杂志》
CAS
2021年第4期267-271,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
双歧四联活菌片
复方消化酶胶囊
小儿
厌食症
胃肠激素
bifido tetragenous viable bacterium tablets
compound digestive enzyme capsules
children
anorexia
gastrointestinal hormones
