摘要
目的探讨男性精子畸形对体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)治疗结局的影响。方法回顾性分析2016年1月至2017年12月在成都市妇女儿童中心医院生殖中心接受IVF-ET助孕治疗的753例患者的临床资料,根据正常形态精子比率将其分为3组:A组,重度畸形精子症组,精子形态正常率<1%,共191例;B组,畸形精子症组,精子形态正常率1%~4%,共367例;C组,为对照组,精子形态正常率≥4%,共195例。结果与C组相比,A组、B组的精子密度,前向运动精子数均显著下降(P<0.01);A组行常规IVF时,受精率有下降(P<0.01)。所有周期中,A组采用卵胞浆内单精子注射授精占比显著增加(P<0.01),胚胎种植率和临床妊娠率较C组有所下降,流产率有增加,但差异均无统计学意义(P>0.05);精子畸形并伴有活力异常时,受精率和优胚率下降显著(P<0.01),但临床妊娠率和流产率均无统计学差异(P>0.05)。结论IVF中精子畸形仅在其同时伴有精子活力下降时,对受精率和优质胚胎率有影响,对妊娠结局无影响。
Objective To explore the influence of male sperm deformity on the outcome of in vitro fertilization and embryo transfer(IVF-ET)treatment.Methods A retrospective analysis of the clinical treatment outcomes of 753 patients who received IVF-ET in the Reproductive Center of Chengdu Women’s and Children’s Central Hospital from January 2016 to December 2017 was divided into three groups according to the ratio of normal morphological sperm:In the severe teratozoospermia group(group A),the normal sperm morphology rate was less than 1%,with a total of 191 cases;the general teratozoospermia group(group B),the normal sperm morphological rate was 1%to 4%,with a total of 367 cases;group C was a normal control group with sperm The morphological normal sperm morphology rate was≥4%,with a total of 195 cases.Results Compared with group C,the sperm density and the number of forward-moving sperm in group A,B were significantly decreased(P<0.01);the fertilization rate of the severely deformed sperm group was decreased when routine IVF insemination was performed(P<0.01).In all cycles,the percentage of insemination with intracytoplasmic sperm injection(ICSI)in group A increased significantly(P<0.01),the embryo implantation rate and clinical pregnancy rate decreased compared with group C,and abortion rate increased,but the difference was not statistically significant(P>0.05);when the sperm deformity was accompanied by abnormal motility,the fertilization rate and the excellent embryo rate decrease significantly(P<0.01),but there was no statistical difference on the clinical pregnancy rate and abortion rate(P>0.05).Conclusion Sperm abnormalities in IVF only affect the rate of fertilization and high-quality embryos when they are accompanied by decreased sperm motility,but have no effect on the outcome of pregnancy.
作者
段霜
鲜红
王芳
滕文顶
张攀
何生燕
杨付桥
DUAN Shuang;XIAN Hong;WANG Fang;TENG Wending;ZHANG Pan;HE Shengyan;YANG Fuqiao(Department of Reproduction and Infertility,The Affiliated Hospital,School of Medicine,UESTC Chengdu Women’s and Children’s Central Hospital,Chengdu Sichuan 610091,P.R.China)
出处
《中国计划生育和妇产科》
2021年第4期37-41,共5页
Chinese Journal of Family Planning & Gynecotokology
关键词
体外受精-胚胎移植
畸形精子
妊娠率
种植率
in vitro fertilization-embryo transfer
abnormal sperm
pregnancy rate
implantation rate
