摘要
成功妊娠的建立和维持需要黄体产生的类固醇激素的精细调控,雌激素、孕激素均在妊娠早期发挥重要作用。早孕期胚胎的发育需要一定量的雌激素维持,孕激素在雌激素水平的基础上升高,为诱导子宫内膜蜕膜化提供条件。当孕激素分泌不足时,将影响胚胎着床和生长,引起流产。雌、孕激素在妊娠早期协同作用,在维持子宫内膜蜕膜化方面发挥重要作用。目前临床上应用孕激素、雌激素预防流产以及黄体功能不全患者的激素补充多基于临床经验,尚缺乏足够的循证医学证据。早孕期补充雌、孕激素"保胎"需要更加慎重,避免不必要的过度用药。
The establishment and maintenance of a successful pregnancy requires the fine regulation of steroid hormones produced by the corpus luteum. Estrogen and progesterone play a major role in early pregnancy. The development of early pregnancy embryo needs a certain amount of estrogen to maintain,and the increase of progesterone on the basis of estrogen level provides the conditions for inducing endometrium decidualization. Insufficient production of progesterone will affect embryo implantation and growth,and eventually lead to miscarriage. Therefore,both estrogen and progesterone play an important role in maintaining endometrium decidualization in early pregnancy. At present,the clinical application of progesterone and estrogen to prevent abortion and hormone supplementation in patients with luteal insufficiency are mostly based on clinical experience,and are still lacking sufficient evidence-based medical evidence.Therefore,the supplementation of estrogen and progesterone in early pregnancy to "keep the fetus" needs to be more cautious,and unnecessary drugs should be avoided.
作者
尹相杰
李昆明
段涛
YIN Xiang-jie;LI Kun-ming;DUAN Tao(Shanghai First Maternity and Infant Hospital,Tongji University School of Medicine,Shanghai 201204,China)
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2021年第4期414-417,共4页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
妊娠期黄体
孕激素
雌激素
早孕期
pregnant corpus luteum
progesterone
estrogen
early pregnancy
