摘要
目的探讨血清糖类抗原125(CA125)、孕酮水平及血糖波动幅度与早期先兆流产预后的相关性分析。方法抽取2020年1月至2022年1月菏泽市妇幼保健院收治的120例早期先兆流产孕妇作为研究对象,根据妊娠结局分为继续妊娠组86例和难免流产组34例,另抽取60例同期产检的正常妊娠孕妇作为正常妊娠组。收集入组对象的一般资料,比较三组孕妇孕4、6、8、10周时血清CA125、孕酮水平和血糖波动幅度,分析其与早期先兆流产预后的相关性。结果随着孕周的增加,继续妊娠组、正常妊娠组孕妇血清CA125水平均呈现下降趋势,难免流产组孕妇CA125水平呈现上升趋势,且难免流产组孕妇血清CA125水平高于继续妊娠组,继续妊娠组孕妇血清CA125水平高于正常妊娠组(P<0.05);三组孕妇血清孕酮水平均呈上升趋势,且难免流产组孕妇血清孕酮水平低于继续妊娠组(P<0.05),继续妊娠组孕酮水平低于正常妊娠组(P<0.05);三组孕妇血糖波动幅度均呈上升趋势,且难免流产组孕妇血糖波动幅度高于继续妊娠组(P<0.05),继续妊娠组孕妇血糖波动幅度高于正常妊娠组(P<0.05)。结论早期先兆流产预后不良与血清CA125升高、孕酮水平降低和血糖波动幅度较大有关,可动态检测该三项指标以指导临床是否给予保胎治疗。
Objective To investigate the correlation of levels of serum carbohydrate antigen 125(CA125),progesterone and amplitude of blood glucose fluctuation with prognosis of patients with early threatened abortion.Methods A total of 120 pregnant women with early threatened abortion admitted to Heze Maternal and Child Health Care Hospital from January 2020 to January 2022 were selected as the research objects.According to pregnancy outcome,they were divided into continued gestation group(86 cases)and inevitable abortion group(34 cases).Another 60 normal pregnant women during the same period were selected as the normal pregnancy group.The general data of all selected objects were collected.The levels of serum CA125,progesterone and amplitude of blood glucose fluctuation were compared among the three groups at 4,6,8 and 10 weeks of pregnancy.The correlation between the three factors and the prognosis of early threatened abortion was analyzed.Results With the increase of gestational weeks,the level of serum CA125 decreased in the continued gestation group and the normal pregnancy group,while the levels of serum CA125 increased in the inevitable abortion group,moreover,the levels of serum CA125 in the inevitable abortion group was the highest,followed by the continued gestation group and the normal pregnancy group(P<0.05).There was a uptrend in serum progesterone level of the three groups,moreover,the serum progesterone level in the normal pregnancy group was the highest,followed by the continued gestation group and the inevitable abortion group(P<0.05).The amplitude of blood glucose fluctuation in the three groups increased,and the index in the inevitable abortion group was the highest,followed by the continued gestation group and the normal pregnancy group(P<0.05).Conclusions The poor prognosis of early threatened abortion is related to continuous increase of serum CA125,decrease of serum progesterone and great amplitude of blood glucose fluctuation.The three indicators can be dynamically tested to guide the treatment of fe
作者
贾瑞如
刘媛
Jia Ruiru;Liu Yuan(Department of Laboratory,Heze Maternal and Child Health Care Hospital,Heze 274000,China)
出处
《中国实用医刊》
2023年第2期1-4,共4页
Chinese Journal of Practical Medicine
关键词
先兆流产
血清糖类抗原125
孕酮
血糖波动幅度
预后
Abortion,threatened
Serum carbohydrate antigen 125
Progesterone
Amplitude of blood glucose fluctuation
Prognosis
