摘要
脑缺血再灌注损伤(CIRI)是严重危害人类健康的复杂的病理生理过程,其中炎症反应是诱发CIRI的重要因素之一,大量炎症因子诱导神经元凋亡或坏死,并介导微血管功能障碍,继发脑出血或脑水肿,对机体造成不可逆的损伤。因此寻求针对CIRI的有效防护和治疗策略具有重要意义。本文介绍白细胞介素(IL)-1、肿瘤坏死因子-α和IL-6等炎症因子在CIRI过程中发挥的生理功能,列举近年将炎症因子作为靶点CIRI相关的药物和天然产物,为临床针对性地治疗CIRI提供依据。
Cerebral ischemia-reperfusion injury(CIRI)is a complex pathophysiological process and seriously endanger human health,in which inflammatory reaction is one of the important factors to induce CIRI.A large number of inflammatory factors effect neuronal apoptosis or necrosis,mediate microvascular dysfunction,and lead to cerebral hemorrhage or cerebral edema,causing irreversible damage to the body.Therefore,it is of great significance to seek effective prevention and treatment strategies for CIRI.This review introduces the physiological functions of inflammatory factors such as interleukin(IL)-1,tumor necrosis factorαand IL-6 in the process of CIRI,and lists the drugs and natural extracts related to inflammatory factors in recent years,so as to provide evidence for the clinical treatment of CIRI.
作者
任靓明
田红旗
REN Jingming;TIAN Hongqi(Institute of Radiation Medicine,Peking Union Medical College&Chinese Academy of Medical SciencesTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Tianjin300192,China)
出处
《中国医药导报》
CAS
2021年第12期61-64,共4页
China Medical Herald
基金
天津市科技计划项目(19YFZCSY00350、17ZXX YSY00090)
中国医学科学院放射医学研究所协助开发(委托)基金项目(IRM-QT2020045)。
关键词
脑缺血
再灌注损伤
细胞因子
炎症因子抑制剂
Brain ischemia
Reperfusion injury
Cytokines
Anti-Inflammatory agents
