摘要
目的比较飞秒激光制瓣的准分子激光原位角膜磨镶术(FS-LASIK)与全飞秒激光小切口角膜基质内透镜取出术(SMILE)对屈光不正患者眼表的影响。方法选取2018年1月至2019年6月于郑州大学第一附属医院行角膜屈光手术的63例(126眼)屈光不正患者进行观察。根据患者接受的手术方式不同分为两组,FS-LASIK组31例(62眼),SMILE组32例(64眼),术后随访6个月,观察并收集数据。观察指标包括眼表疾病指数(OSDI)量表评分、角膜荧光素染色评分、泪河高度(TMH)、非侵入式泪膜破裂时间(NIKBUT)、脂质层厚度、睑板腺功能评估得分、眼红指数(HI)。对两组患者各项指标进行统计学分析。结果FS-LASIK组患者术后1周、1个月、6个月OSDI评分较术前均增加,差异均有统计学意义(均为P<0.05);在术后1周时OSDI评分增加最明显。SMILE组患者术后1周、1个月OSDI评分较术前增加,差异均有统计学意义(均为P<0.05)。两组患者术后1周、1个月、6个月OSDI评分相比,差异均有统计学意义(均为P<0.05),FS-LASIK组均高于SMILE组。两组患者术后1周角膜荧光素染色评分均较术前提高,差异均有统计学意义(均为P<0.05);术后1个月、6个月与术前相比,差异均无统计学意义(均为P>0.05)。FS-LASIK组患者术后1周、1个月、6个月TMH与术前相比均减小,差异均有统计学意义(均为P<0.05),且在术后1周减小最为显著。SMILE组患者术后1周、1个月TMH亦均较术前减小(均为P<0.05)。FS-LASIK组患者术后1周、1个月、6个月NIKBUT与术前相比均减小,差异均有统计学意义(均为P<0.05),且在术后1周减小最为显著。SMILE组患者术后1周、1个月、6个月NIKBUT与术前相比均减小,差异均有统计学意义(均为P<0.05)。两组患者术后1周、1个月、6个月NIKBUT相比,差异均有统计学意义(均为P<0.05),FS-LASIK组均小于SMILE组。FS-LASIK组患者术后1周、1个月、6个月脂质层厚度均较术前减小,差异�
Objective To compare the effects of femtosecond laser in situ keratomileusis(FS-LASIK)and full femtosecond laser small incision corneal stromal lens removal(SMILE)on ocular surface of patients with ametropia.Methods A total of 63 patients(126 eyes)with ametropia who underwent corneal refractive surgery in the First Affiliated Hospital of Zhengzhou University from January 2018 to June 2019 were selected.According to different surgical methods,the patients were divided into two groups 31 patients(62 eyes)in the FS-LASIK group and 32 patients(64 eyes)in the SMILE group.The patients were followed up for 6 months to observe and collect data.Observation indicators included ocular surface disease index(OSDI)scale score,corneal fluorescein staining score,tear meniscus height(TMH),non-invasive Keratograph tear film break-up time(NIKBUT),lipid layer thickness,meibomian gland function evaluation score,and ocular redness index(HI).Results The OSDI scores of FS-LASIK group increased 1 week,1 month and 6 months after surgery compared with those before surgery,and the differences were statistically significant(all P<0.05).The OSDI score increased most significantly at 1 week postoperatively.OSDI scores of SMILE group increased 1 week and 1 month after surgery compared with those before surgery,and the differences were statistically significant(both P<0.05).There were statistically significant differences in OSDI scores between the two groups at 1 week,1 month and 6 months after surgery(all P<0.05),and the FS-LASIK group was higher than the SMILE group.The corneal fluorescein staining score was increased 1 week after surgery in both groups compared with that before surgery,with statistical significance(both P<0.05);there was no significant difference between 1 month and 6 months after operation and before operation(all P>0.05).TMH in FS-LASIK group decreased 1 week,1 month and 6 months after surgery compared with that before surgery,with statistically significant differences(all P<0.05),and the decline was most significant at 1
作者
孙广莉
韩文杰
刘方
苏刚
SUN Guangli;HAN Wenjie;LIU Fang;SU Gang(Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China;Department of Ophthalmology,Xuchang Central Hospital,Xuchang 461000,Henan Province,China)
出处
《眼科新进展》
CAS
北大核心
2021年第4期333-337,共5页
Recent Advances in Ophthalmology
基金
河南省高等学校重点科研项目(编号19A320012)。
