摘要
目的:应用眼表综合分析仪研究飞秒激光辅助的准分子激光原位角膜磨镶术(femtosecond laser-assisted laser in situ keratomileusis,FS-LASIK)、经上皮准分子激光角膜切削术(transepithelial photorefractive keratectomy,T-PRK)和全飞秒小切口透镜取出术(small incision lenticule extraction,SMILE)后干眼症状和体征的变化。方法:收集2017-01/05在我院行角膜屈光手术患者98例196眼,按术式分三组:FS-LASIK组、T-PRK组和SMILE组。所有患者术前和术后1wk,1、3、6mo均行以下检查:眼表疾病指数(ocular suface disease index,OSDI)问卷、眼表综合分析仪红外线下泪河高度测量(tear meniscus height,TMH)、红外线首次泪膜破裂时间(the first tear film break-up time,FBUT)和平均泪膜破裂时间(average tear film break-up time,ABUT)测量、角膜荧光素染色(comeal fluorescence staining,FL)、基础泪液分泌试验Ⅰ(SchirmerⅠtest,SⅠt)。结果:(1) OSDI指数:三组患者间术后OSDI差异有统计学意义(F_(组间)=2. 799,P_(组间)<0. 05)。但各组不同时间点的OSDI值差异具有统计学意义(F_(时间)=85. 942,P_(时间)<0. 001)。各组患者OSDI指数术后1wk,1、3mo时较术前明显增加,术后6mo各组患者均恢复到术前水平。术后3mo时,各组患者OSDI值差异有统计学意义(P=0. 019),其中T-PRK组的OSDI值较其它两组高。(2) TMH:三组患者间术后TMH差异有统计学意义(F_(组间)=1. 720,P_(组间)<0. 05)。各组患者不同时间点的TMH值差异有统计学意义(F_(时间)=11. 202,P_(时间)<0. 001)。各组患者TMH值在术后1wk和1mo时较术前明显降低,术后3、6mo恢复至术前水平。术后3mo时,各组TMH值差异有统计学意义(P=0. 004),其中SMILE组的下泪河高度高于其它两组。(3) FBUT:术后三组患者间FBUT差异无统计学意义(F_(组间)=1. 428,P_(组间)=0. 245)。各组内不同时间点的FBUT值差异有统计学意义(F_(时间)=4. 511,P_(时间)=0. 001)。各组FBUT值在术后1wk、1mo时较术前明显降�
AIM：To compare dry eye symptoms and signs beforeand after three kinds surgery, femtosecond laser-assistedlaser in situ keratomileusis （ FS - LASIK）, transepithelialphotorefractive keratectomy （ T - PRK ）, small incisionlenticule extraction （SMILE） using ocular surface analyzer（Oculus Keratograph）.METHODS： Totally 98 patients （ 196 eyes） undergoingcorneal refractive surgery from January 2017 to May 2017were recruited. They were divided into three groups,namely, FS - LASIK group, T - PRK group and SMILEgroup. All patients underwent observation andassessment in the following order： ocular surface diseaseindex （ OSDI）, tear meniscus height （ TMH）, measureusing the infrared pattern of Oculus Keratograph. The firsttear film break-up time （FBUT） and average tear break-up time （ ABUT） measure using the infrared pattern ofOculus Keratograph, corneal fluorescein staining （ FL）,Schirmer ｜ test （S｜t）. RESULTS： 1 ） OSDI index： There was statisticallysignificant difference between the three groups （ Fgroups =2. 799, Pgroups 〈0. 05）. However, the difference in the OSDIvalues of different time points in each group wasstatistically significant （ Ftime = 85. 942, Ptime 〈 0. 001 ）. TheOSDI index were significantly increased at 1wk, 1 and 3moafter operation in each group. All groups recovered to thepreoperative level at 6mo after operation. After 3mo,there was an inter - group difference in the OSDI values（P= 0. 019 ）, and the OSDI values of the T - PRK groupwere higher than those of the other two groups. 2） TMH：There was statistically significant difference among thethree groups postoperatively （ Fgroups = 1. 720, Pgroups 〈0. 05）. The TMH values of different time points in eachgroup were significantly different （ Ftime = 11. 202, Ptime 〈0. 001）. The TMH values of each group were significantlyreduced after 1wk and 1mo and were restored topreoperative levels after 3 and 6mo. After 3mo, there wasa difference TMH among the three groups （ P = 0
作者
李瑞霞
沈政伟
揭黎明
郑林
Rui-Xia Li;Zheng-Wei Shen;Li-Ming Jie;Lin Zheng(Department of Optometry,Affiliated Xiamen Eye Center of XiamenUniversity,Xiamen 361003,Fujian Province,China)
出处
《国际眼科杂志》
CAS
北大核心
2018年第11期2051-2055,共5页
International Eye Science
基金
厦门市医学科研计划项目(No.2014-2-81)
