摘要
皮肤恶性肿瘤是人类肿瘤中最常见的一种,全球范围内其发病率正在逐年上升,而导致患者发生死亡的主要原因是肿瘤的侵袭和转移。肿瘤转移是多因素、多阶段的,其过程复杂。目前临床上对皮肤恶性肿瘤转移机制的研究尚有很多未知领域。本文从不同角度对皮肤恶性肿瘤转移机制相关的分子生物学、非编码RNA、EMT及肿瘤微环境等方面进行了综述,随着研究的不断深入,期待在肿瘤转移机制中寻找肿瘤治疗的新的靶点,为提高皮肤恶性肿瘤患者生存率和生活质量提供新的契机。
Skin malignant tumors are the most common type of human tumors,and their incidence is increasing year by year worldwide.The main cause of death of patients is tumor invasion and metastasis.Tumor metastasis is multi-factor and multi-stage,and its process is complicated.At present,there are still many unknown areas in clinical research on the metastasis mechanism of skin malignant tumors.This article reviews the molecular biology,non-coding RNA,EMT,and tumor microenvironment related to skin malignant tumor metastasis from different perspectives.With the deepening of research,we look forward to finding new tumor treatments in tumor metastasis mechanisms.The target provides a new opportunity for improving the survival rate and quality of life of patients with skin malignant tumors.
作者
贾敏鑫
李东霞
JIA Min-xin;LI Dong-xia(Department of Dermatology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia,China)
出处
《医学信息》
2021年第8期36-40,共5页
Journal of Medical Information
基金
2016年“草原英才”高层次培养人才项目(编号:CYYC6027)
2020年内蒙古自然科学基金项目(编号:2020LH08018)。
关键词
皮肤恶性肿瘤
分子生物学
肿瘤微环境
Skin malignant tumor
Molecular biology
Tumor microenvironment
