摘要
目的探讨转移相关蛋白2(metastasis-associated protein 2,MTA2)在卵巢上皮性癌组织中的表达及其预后价值。方法采用免疫组化SP法检测91例卵巢石蜡包埋组织中MTA2蛋白的表达情况,采用Western blot法检测卵巢新鲜组织中MTA2的表达,同时结合患者随访资料进行预后分析。结果 MTA2在卵巢良性囊肿(17. 5%)和卵巢上皮性癌(78. 43%)中的阳性率逐渐升高(χ~2=33. 328,P <0. 001),MTA2表达与卵巢上皮性癌FIGO分期及淋巴结转移显著相关(P均<0. 05); MTA2在卵巢良性囊肿和卵巢上皮性癌中的相对表达量分别是0. 58±0. 05、1. 22±0. 10,差异有统计学意义(t=-22. 274,P <0. 001);MTA2阳性与阴性患者的生存曲线差异有统计学意义(χ~2=10. 203,P <0. 05);多因素回归分析表明MTA2蛋白表达、FIGO分期及淋巴结转移是卵巢上皮性癌有效的独立预后指标(P均<0. 05)。结论 MTA2可能作为一个癌基因参与卵巢上皮性癌的发展和转移,MTA2过表达预示患者预后不良。
Purpose To analyze the expression and prognostic value of metastasis-associated protein 2(MTA2)in epithelial ovarian carcinoma.Methods The expression of MTA2 protein was examined in 91 paraffin-embedded specimens by immunohistochemical SP method,and in fresh specimens by Western blot,and then combined with follow-up data for prognosis analysis.Results There was an increasing tendency in positive rate of MTA 2 expression from benign ovarian cysts(17.5%)to epithelial ovarian cancers(78.43%),and there were significant difference(χ2=33.328,P<0.001).The expression of the MTA2 was significantly correlated to FIGO stage and lymph node metastasis(both P<0.05).The relative expression of MTA2 in benign ovarian cysts and epithelial ovarian cancers was 0.58±0.05,and 1.22±0.10,respectively,and the difference was statistically significant(t=-22.274,P<0.001).The survival curve of patients with MTA2(+)differed from the survival curve of patients with MTA2(-)and the difference was statistically significant(χ2=10.203,P<0.05).The multiple factor analysis revealed that the expression of MTA2,FIGO stage and lymph node metastasis were independent prognostic factors for clinical outcome of epithelial ovarian cancer.Conclusion MTA2 may be involved in the progression and metastasis of epithelial ovarian cancer as an oncogene.Overexpression of the marker indicates poor prognosis of patients.
作者
甄娟
刘玉东
宋春红
王莉
朱玉芬
朱晓艳
ZHEN Juan;LIU Yu-dong;SONG Chun-hong;WANG Li;ZHU Yu-fen;ZHU Xiao-yan(Department of Pathology,Shijiazhuang Fourth Hospital/Obstetrics and Gynecology Hospital of Shijiazhuang,Shijiazhuang 050000,China;Department of Otolaryngology,Hebei General Hospital,Shijiazhuang 050057,China)
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2019年第3期304-308,共5页
Chinese Journal of Clinical and Experimental Pathology
基金
石家庄市科学技术研究与发展指导计划(171462003)
关键词
卵巢肿瘤
卵巢上皮性癌
MTA2
临床病理参数
预后
ovarian neoplasm
epithelial ovarian cancer
MTA2
clinicopathological parameters
prognosis
