摘要
目的探讨P53、B细胞淋巴瘤/白血病-2基因(bcl-2)蛋白在基底细胞癌(BCC)组织中的表达及临床意义。方法用免疫组化链霉素抗生素蛋白-过氧化物酶连结(SP)法检测P53、Bcl-2蛋白在40例BCC(BCC组)组织中的表达,以20例正常皮肤组织作为对照组。结果 P53、Bcl-2蛋白在BCC组表达阳性率分别为55%(22/40)、85%(34/40),在对照组表达阳性率分别为15%(3/20)、10%(2/20)。P53、Bcl-2蛋白在BCC组中的表达明显强于对照组,差异有统计学意义(χ2=6.35、7.45,P<0.01)。结论 P53、Bcl-2蛋白的异常表达与BCC相关,说明其可能在BCC的发生及发展过程中起重要作用。
Objective To investigate the expression and clinical significance of protein P53 and B cell lymphom/leukemia-2 gene（Bcl-2） in basal cell carcinoma（BCC）. Methods The expression of protein P53 and Bcl-2 was measured by streptavidin-peroxidase（SP） immunohistochemical method in 40 cases of BCC（BCC group）,and 20 cases of normal skin tissue were selected as control group. Results The positive rates of protein P53 and Bcl-2 in the BCC group were 55%（22/40） and 85%（34/40） respectively,while they were 15%（3/20） and 10%（2/20） respectively in the control group. The expression of pro-tein P53 and Bcl-2 in the BCC group was significantly stronger than that in the control group with statistically significant differ ence（χ2=6.35,7.45;P＆lt;0.01）. Conclusion The abnormal expression of protein P53 and Bcl-2 is related with BCC,which shows that protein P53 and Bcl-2 might play an important role in the occurrence and development of BCC .
出处
《现代医药卫生》
2014年第7期977-978,共2页
Journal of Modern Medicine & Health
