摘要
精子发生(spermatogenesis)包括精原细胞的有丝分裂、精母细胞的减数分裂以及精子细胞的变形,是人体最复杂的细胞分化过程之一。其中人类男性个体进入青春期后才开始减数分裂之后的过程。一个世纪以来,科学家们一直在努力开发和优化能够在体外(in vitro)支持这一过程的培养体系。近年来,体外精子发生的研究取得了显著进展,根据目前所采用的研究方法,体外精子发生的相关研究主要可以分为细胞培养法和性腺组织培养法。体外精子发生系统的建立对于完善人类生殖生物学理论,不育相关环境因素的体外评价,以及生育力保存技术等均具有非常重要的意义。
Spermatogenesis,including mitosis of spermatogonia,meiosis of spermatocytes and spermiogenesis of spermatids,is one of the most complicated cell differentiation processes in human body. The process of meiosis begins after puberty. For a century,scientists have been working on developing and optimizing culture systems that can support this process in vitro. In recent years,significant progress has been made in the study of in vitro spermatogenesis. The in vitro spermatogenesis can be achieved by in vitro cell culture and gonadal tissue culture. The establishment of in vitro spermatogenesis system is important for the development of theories of human reproductive biology,in vitro evaluation of infertility-related environmental factors,and technologies of fertility preservation.
作者
郭雪江
GUO Xuejiang(State Key Laboratory of Reproductive Medicine,Department of Histology and Embryology,Nanjing Medical University,Nanjing 211166,China)
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2021年第2期157-159,180,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家重点研发计划(2016YFA0503300)
国家自然科学基金(81971439,81771641)。
