摘要
胆固醇是哺乳动物体内重要的脂质,是必不可少的膜结构成分。胆固醇稳态平衡对维持细胞和机体的生命活动至关重要,机体主要通过内源胆固醇的生物合成和外源胆固醇的摄取来获得胆固醇以维持自身稳态平衡。肿瘤细胞中胆固醇代谢异常活跃,导致其增殖、存活、侵袭、转移以及对肿瘤微环境的适应能力增强。靶向胆固醇合成、降低血浆胆固醇水平和胆固醇酯化的治疗策略将为肿瘤患者的治疗带来新的希望。本文总结了胆固醇代谢调节及其在肿瘤发生发展中的研究进展,并讨论了目前干扰胆固醇代谢的肿瘤治疗新方法。
Cholesterol is an important lipid in the body of mammals and an essential component of membrane structures.Cholesterol homeostasis is critical for the maintenance of cellular and body activities,and is mainly regulated by the balance of de novo cholesterol biosynthesis and the exogenous cholesterol uptake.Aberrantly regulated cholesterol metabolism promotes tumor cell proliferation,survival,invasion and metastasis,and their adaptability into the tumor microenvironment.Therefore,targeting cholesterol biosynthesis and reduction of plasma cholesterol levels and cholesterol esterification will provide new strategies for cancer treatment.This review summarizes the current understanding in cholesterol homeostasis regulation and its function in the occurence and development of cancer,as well as current metabolism-targeted cancer treatments.
作者
孟颖
王启扉
吕志民
MENG Ying;WANG Qifei;LYU Zhimin(Zhejiang Provincial Key Laboratory of Pancreatic Disease,Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou 310029,China)
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2021年第1期23-31,共9页
Journal of Zhejiang University(Medical Sciences)
基金
科技部重点研发计划(2020YFA0803300)
浙江省引进培育领军型创新创业团队(2019R01001)。
关键词
胆固醇
代谢
肿瘤
治疗
综述
Cholesterol
Metabolism
Tumor
Therapy
Review
