摘要
目的:研究颈动脉彩超联合S100-β蛋白检测在动脉粥样硬化性脑梗死中的诊断效果。方法:选取2018年1月-2019年3月本院收治的动脉粥样硬化性脑梗死患者45例作为研究组,选取同期本院45例健康体检者为对照组。采用颈动脉彩超检测动脉内膜斑块形成情况及颈动脉内-中膜厚度(IMT),测定血清S100-β蛋白与C反应蛋白(CRP)含量,根据NIHSS评分将研究组患者分为轻、中、重度。比较两组颈动脉斑块检出情况和IMT、S100-β蛋白、CRP水平;比较研究组不同情况患者的S100-β蛋白、CRP水平及IMT;使用Pearson相关分析法判断S100-β蛋白含量与CRP、NIHSS评分、IMT的相关性。结果:研究组的颈动脉斑块检出率为91.11%,显著高于对照组的75.56%,在阳性者中,研究组不稳定斑块的检出率显著高于对照组(P<0.05)。研究组IMT、S100-β、CRP均高于对照组(P<0.05)。不同病情、不同梗死面积患者的IMT、S100-β、CRP比较,差异均有统计学意义(P<0.05)。功能缺损程度越重,梗死面积越大,S100-β蛋白与CRP水平越高,IMT厚度越大(P<0.05)。Pearson相关分析结果表明CRP、NIHSS评分、IMT与S100-β蛋白含量均呈正相关性(P<0.05)。结论:颈动脉彩超可以有效检出脑梗死的动脉粥样硬化,联合S100-β蛋白检测,可以有利于患者病情发展程度的判断,提高动脉粥样硬化性脑梗死中的诊断率,对预防与治疗动脉粥样硬化性脑梗死具有较高的临床价值。
Objective:To study the diagnostic effect of carotid ultrasound combined with S100-βprotein detection in atherosclerotic cerebral infarction.Method:A total of 45 patients with atherosclerotic cerebral infarction admitted to our hospital from January 2018 to March 2019 were selected as the study group,and 45 healthy physical examination subjects admitted to our hospital during the same period were selected as the control group.Carotid artery color doppler ultrasound was used to detect the intimal plaque formation and carotid intima-media thickness(IMT),and serum S100-βprotein and C-reactive protein(CRP)content were determined.The patients in the study group were divided into mild,moderate and severe groups according to the NIHSS score.The levels of IMT,S100-βprotein and CRP were compared between the two groups.The levels of S100-βprotein,CRP and IMT in patients with different conditions were compared.Pearson correlation analysis were used to determine the correlation between S100-βprotein content and CRP,NIHSS score and IMT.Result:The detection rate of carotid plaque in the study group was 91.11%,significantly higher than 75.56%in the control group,among the positive subjects,the detection rate of unstable plaque in the study group was significantly higher than that in the control group(P<0.05).IMT,S100-βand CRP in the study group were higher than those in the control group(P<0.05).Comparison of IMT,S100-βand CRP in patients with different disease and infarct area,the differences were statistically significant(P<0.05).The more severe the defect,the larger the infarct area,the higher the level of S100-βprotein and CRP,and the greater the IMT thickness(P<0.05).Pearson correlation analysis showed that CRP,NIHSS score,IMT and S100-βprotein content were positively correlated(P<0.05).Conclusion:Carotid artery color doppler ultrasound can effectively detect the atherosclerosis of cerebral infarction,combined with S100-βprotein detection,can be beneficial to the judgment of the degree of disease development of pa
作者
王浩
蔺慕会
WANG Hao;LIN Muhui(Liaoning Provincial People’s Hospital,Shenyang 110000,China;不详)
出处
《中国医学创新》
CAS
2021年第1期66-69,共4页
Medical Innovation of China
