摘要
目的探讨癫痫患者人格改变及其与外周血中异常表达的lncRNA水平的关系。方法以方便取样法选取58例癫痫患者(研究组)采用人格诊断问卷进行人格改变筛查;以qRT-PCR筛查研究组和58例健康体检人员(对照组)外周血lncRNA表达水平,对数据进行描述性统计分析、相关分析、回归分析、ROC分析等统计学处理。结果发现癫痫患者有9人为分裂样(S≥4)、11人为分裂型(S≥5)、17人为偏执型(S≥4)、15人为强迫型(S≥4)人格改变,有52人存在不同类型人格改变(89.66%)。分裂样、分裂型、偏执型、强迫型人格改变与NONHSAG012869(PR3),NONHSAT006265(PR4),ENST00000581634(PR6),ENST00000524610(PR8)表达水平显著负相关(r=-0.46~-0.71,P<0.05或P<0.01)。PR1、PR3、PR8对分裂样人格改变有显著预测作用(P<0.01),对分裂样人格改变的解释率为0.36;PR4、PR8对分裂型人格改变有显著预测作用(P<0.01),对分裂型人格改变的解释率为0.30;PR3、PR4、PR6对偏执型人格改变有显著预测作用(P<0.05),对偏执型人格改变的解释率为0.40;PR4、PR5、PR8对强迫型人格改变有显著预测作用(P<0.05),对强迫型人格改变的解释率为0.20。癫痫研究组lncRNA表达水平对人格改变诊断价值的ROC曲线分析发现,NONHSAG012869(PR3)、NONHSAT006265(PR4)、ENST00000581634(PR6)、ENST00000524610(PR8)对癫痫患者人格改变有一定的预测价值(AUC:0.650~0.682,P<0.05,95%CI:0.546~0.784)。结论癫痫患者分裂样、分裂型、偏执型、强迫型人格改变常见,外周血lncRNA表达水平对其人格改变有一定诊断价值。
Objective To explore personality change and its association with lncRNA expression of peripheral blood mononuclear cells in patients with epilepsy.Methods Fifty-eight epilepsy patients recruited by the convenient sampling were assessed utilizing personality diagnostic questionnaire(PDQ)for personality change screening.The expression levels of lncRNA in peripheral blood of study group and the controls were investigated by qRT-PCR.Descriptive statistical analysis,correlation analysis,regression analysis and ROC analysis were employed for data processing.Results There were 9 of schizoid(S≥4),11 of schizotypal(S≥5),17 of paranoid(S≥4)and 15 of compulsive(S≥4)personality change in epilepsy patients,and 52 patients had different types personality changes(89.66%).Schizoid,schizotypal,paranoid and compulsive personality changes were negatively correlated with expression levels of NONHSAG012869(PR3),NONHSAT006265(PR4),ENST00000581634(PR6)and ENST00000524610(PR8)(r=-0.46--0.71,P<0.05 or 0.01).PR1,PR3,and PR8 had significant predictive effects on schizoid personality change(P<0.01),PR4,PR8 had a significant predictive effect on schizotypal personality change(P<0.01),PR3,PR4 and PR6 had significant predictive effects on paranoid personality change(P<0.05),and PR4,PR5,PR8 had significant predictive effects on compulsive personality change(P<0.05).The effects of lncRNAs on the personality change variance accounted for 0.36,0.30,0.40,0.20 respectively.ROC curve analysis of the diagnostic value of lncRNA expression level on personality change in the epilepsy group showed that NONHSAG012869(PR3),NONHSAT006265(PR4),ENST00000581634(PR6)and ENST00000524610(PR8)had certain diagnostic value for personality change.The area under curve(AUC)=0.650-0.682,P<0.05,95%CI:0.546-0.784.Conclusion Schizoid,schizotypal,paranoid,and compulsive personality change are common in epileptic patients,and the expression level of peripheral blood lncRNA has a certain diagnostic value for personality change.
作者
陈升东
孔令明
何明骏
朱晓丽
姚高峰
张理义
Chen Shengdong;Kong Lingming;He Mingjun;Zhu Xiaoli;Yao Gaofeng;Zhang Liyi(Neurological Department,No.904 Hospital of Joint Logistics Support Force,Changzhou 213003,China;Mental Disorder Prevention&Treatment Institution,No.904 Hospital of Joint Logistics Support Force,Changzhou 213003,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2021年第3期238-243,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
东部战区医学科技创新重点课题 (14ZD036)。
关键词
癫痫
外周血单核细胞
差异表达
人格改变
长链非编码RNA
Epilepsy
Peripheral blood mononuclear cell
Differential expression
Personality change
Long non-coding RNA
