摘要
目的了解尘肺病患者的维生素D水平,并分析维生素D与炎症因子、淋巴细胞亚群各指标之间的相关性。方法选取60名老年男性健康体检人员为对照组,182名尘肺病患者为研究组,比较两组的维生素D水平;同时分析研究组维生素D水平、尘肺病期别与炎症因子、淋巴细胞亚群的相关性。结果182名尘肺病患者维生素D缺乏人员的占比高于对照组(P<0.05)。研究组平均25(OH)D水平为(21.55±9.51)ng/mL,显著低于对照组的(27.16±8.12)ng/mL(P<0.01)。182名尘肺病患者的炎症因子,包括白介素2受体(IL-2R)、白介素-6(IL-6)、白介素-8(IL-8)、降钙素原(PCT)、C反应蛋白(CRP)随着尘肺病期别的升高而升高(P<0.05);IL-6在维生素D充足组最低(P<0.05),IL-8、PCT及CRP随着25(OH)D水平的升高逐渐降低(P<0.05);壹期尘肺病患者CD4/CD8值高于贰、叁期患者(P<0.05),CD4+T细胞、L/CD45随着尘肺分期的升高而降低(P<0.05);随着25(OH)D水平的升高,CD4+T细胞占比、L/CD45逐渐升高,而CD8+T细胞逐渐下降;25(OH)D与CRP水平呈弱的负相关(r=-0.191,P<0.05),25(OH)D与IL-10、CD4/CD8值、L/CD45呈弱的正相关(r=0.299、0.176、0.257,P<0.05)。结论尘肺病患者维生素D缺乏或不足率较高,尘肺病患者体内的维生素D可能通过调节炎症因子及细胞因子参与炎症反应及免疫功能。
Objective To understand the vitamin D concentration of pneumoconiosis patients and its correlation with inflammatory factors and lymphocyte subpopulation. Methods Totally 182 pneumoconiosis patients and 60 elderly male healthy persons were studied. The vitamin D levels of the two groups were compared. The correlation of vitamin D level with pneumoconiosis stage,inflammatory factors,and lymphocyte subsets in the study group was analyzed. Results The proportion of vitamin D deficiency in 182 pneumoconiosis patients was higher than that in the control group(P < 0.05).The average level of 25(OH)D in study group was(21.55 ± 9.51)ng/mL,significantly lower than that in the control group[(27.16 ± 8.12)ng/mL](P < 0.01). The level of inflammatory factors,including IL-2 R,IL-6,IL-8,PCT and CRP increased gradually with the increment of pneumoconiosis stage(P < 0.05). IL-6 was the lowest in vitamin D sufficient group(P < 0.05),and IL-8,PCT and CRP decreased with the increase of 25(OH)D level(P < 0.05). The ratio of CD4/CD8 in patients with stage I pneumoconiosis was higher than that in patients with stage 2 and stage 3 pneumoconiosis(P <0.05);CD4+T cells and L/CD45 decreased with the increase of pneumoconiosis stage(P < 0.05). With the increase of25(OH)D level,the ratio of CD4+T cells and L/CD45 increased gradually,while CD8+T cells decreased gradually. There was a weak negative correlation between 25(OH)D and CRP level(r =-0.191,P < 0.05),and a weak positive correlation of 25(OH)D with IL-10,CD4/CD8 ratio,and L/CD45(r = 0.299,0.176,0.257,P < 0.05,respectively). Conclusions Vitamin D deficiency or insufficient was common in pneumoconiosis patients. Vitamin D may be involved in inflammation and immune functions by regulating inflammatory factors and lymphocyte subpopulation.
作者
谢良斌
曹艳梅
闵春燕
XIE Liangbin;CAO Yanmei;MIN Chunyan(Baita Community Health Service Center in Gusu District,Suzhou,Jiangsu 215003,China;Department of Occupational Disease,Suzhou 5th People's Hospital,Suzhou,Jiangsu 215137,China)
出处
《职业卫生与应急救援》
2021年第1期21-26,共6页
Occupational Health and Emergency Rescue
基金
苏州市卫生健康委:同济大学附属上海市肺科医院孙道远教授职业病专家团队(SZYJTD201904)。
关键词
尘肺病
维生素D
炎症因子
淋巴细胞亚群
相关性
pneumoconiosis
vitamin D
inflammatory factors
lymphocyte subpopulation
correlation
