摘要
癫痫是一种常见的慢性中枢神经系统疾病,其中药物抵抗性癫痫的治疗是重点和难点。近些年,随着纳米技术的不断发展,利用一些纳米材料能穿透血脑屏障的特性,纳米材料在精准定位致痫区、抗癫痫药物输送等方面的应用受到了广泛关注。本文介绍了一些目前正在研究使用的脑靶向纳米载体,以及这些纳米载体在药物抵抗性癫痫诊断和治疗方面的研究,期望不久的将来有纳米载体能够对癫痫的临床诊断与治疗提供帮助。
Epilepsy is a common chronic central nervous system disease.The treatment of drug resistant epilepsy is the focus and difficulty.In recent years,with the continuous development of nanotechnology,some nanomaterials can penetrate the blood brain barrier,which makes nanomaterials in the accurate localization of epileptic areas and the delivery of antiepileptic drugs has received extensive attention.In this paper,we introduce some brain targeting nanoparticles that are currently being studied and their research in the diagnosis and treatment of drug resistant epilepsy.It is expected that nanocarriers will be helpful in the clinical diagnosis and treatment of epilepsy in the future.
作者
黎玉丹
周琴
田间
潘松青
LI Yudan;ZHOU Qin;TIAN Jian;PAN Songqin(Dept.of Neurology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China;Wuhan University School of Pharmaceutical Sciences,Wuhan 430071,Hubei,China)
出处
《武汉大学学报（医学版）》
CAS
2020年第6期1023-1026,共4页
Medical Journal of Wuhan University
关键词
药物抵抗性癫痫
纳米载体
靶向治疗
药物输送
致痫区定位
Drug Resistant Epilepsy
Nano-Carrier
Targeted Therapy
Drug Delivery
Epileptogenic Zone Localization
