摘要
目的探讨血脂异常水平与结直肠息肉形成之间的相关性。方法收集90例结直肠息肉患者作为结直肠息肉组,103例健康体检者作为对照组。采集两组血液样本使用自动生化分析仪测量血脂和脂蛋白的浓度。息肉组根据病理特征对大肠病变进行分类:增生性息肉、炎性息肉和腺瘤,腺瘤根据息肉的数量和组织学类型将分为非晚期和晚期腺瘤两类。比较各组血脂和脂蛋白浓度水平的差异。采用受试者工作特征曲线(ROC)分析各指标对结直肠息肉患者的诊断价值。结果结直肠息肉组患者的胆固醇水平低于对照组,甘油三酯和载脂蛋白B水平高于对照组,差异均有统计学意义(t分别=2.23、-3.03、-2.46,P均<0.05),结直肠息肉组中的腺瘤患者甘油三酯、载脂蛋白B均高于对照组,差异均有统计学意义(t分别=-3.36、-2.14,P均<0.05),其中晚期腺瘤患者的低密度脂蛋白、载脂蛋白B水平高于对照组,差异均有统计学意义(t分别=-3.49、-3.22,P均<0.05),甘油三酯和载脂蛋白B对结直肠息肉预测价值的AUC分别为0.59、0.63。结论甘油三酯和载脂蛋白B与息肉的发生有关,联合使用可作为临床诊治结直肠息肉的预测指标。
Objective To explore the relationship between abnormal blood lipid levels and the formation of colorectal polyps.Methods Ninety patients with colorectal polyps were collected as the colorectal polyps group,and 103 healthy subjects were selected as the control group.The levels of blood lipids and lipoproteins were detected.According to the pathological characteristics,the colorectal lesions were classified hyperplastic polyps,inflammatory polyps and adenomas.According to the number and histological type of polyps,adenomas were divided into non-advanced and advanced adenomas.The differences in the levels of blood lipids and lipoproteins were compared.The receiver operating curve(ROC)was used to analyze the diagnostic value of triglyceride and apolipoprotein B in patients with colorectal polyps.Results The cholesterol level of the colorectal polyp group was lower than that of the control group,and the levels of triglyceride and apolipoprotein B were higher than that of the control group,the differences were statistically significant(t=2.23,-3.03,-2.46,P<0.05).The triglycerides and apolipoprotein B in adenoma patients in the colorectal polyp group were higher than those of the control group(t=-3.36,-2.14,P<0.05).The levels of low-density lipoprotein and apolipoprotein B in patients with advanced adenoma in the polyp group were higher than those in the control group(t=-3.49,-3.22,P<0.05).The AUC of the triglyceride area and apolipoprotein B for predictiong colorectal polyps were 0.59 and 0.63 respectively.Conclusion Triglycerides and apolipoprotein B are related to the occurrence of polyps,and can be used as a predictive index for clinical diagnosis and treatment of colorectal polyps.
作者
金辉
盛玲玲
杨再兴
任应鹏
刘东红
盛显仑
JIN Hui;SHENG Lingling;YANG Zaixing(Department of Gastroenterology,Taizhou First People’s Hospital,Taizhou 318020,China)
出处
《全科医学临床与教育》
2021年第3期221-223,235,共4页
Clinical Education of General Practice
基金
浙江省医药卫生科技项目(2020KY1044)
台州市科技计划项目(20ywb62,20ywa42)。
关键词
结直肠息肉
甘油三酯
低密度脂蛋白
载脂蛋白B
colorectal polyps
triglycerides
low density lipoprotein
apolipoprotein B
