摘要
目的代谢综合征(metabolic syndrome,MS)是一组临床症候群,MS及其相关组分与癌症发生发展及病理特征具有密切关系。本研究旨在分析MS及其相关组分与肾透明细胞癌(clear cell cenal cell carcinoma,CCRCC)分期、分级及肿瘤大小的相关性。方法回顾性分析2013-01-01-2015-12-30于山西医科大学第一医院就诊且病理诊断为CCRCC的375例患者的临床资料,包括年龄、性别、身高、体质量、血压、空腹血糖、生化结果、病理分期分级和肿瘤大小等。计数资料采用χ2检验,计量资料以x-±s表示,组间比较采用t检验,多因素分析采用Logistic回归分析。结果 MS组56例患者,其中男性患者32例,女性患者24例;非MS组319例患者,其中男性患者206例,女性患者113例。男女患者比较,差异无统计学意义,P=0.287。MS组与非MS组相比,年龄、吸烟、饮酒等差异无统计学意义,P值分别为0.100、0.691和0.269;而BMI指数、收缩压、空腹血糖、TG、HDL-C等差异均有统计学意义,均P<0.001。在病理特点方面,MS与非MS相比,CCRCC病理分期(P=0.018)、分级(P=0.026)及肿瘤大小(P=0.026),差异均有统计学意义。MS相关疾病与CCRCC分期分析,糖尿病(P<0.001)、高血压(P=0.015)、血脂紊乱(P=0.006)与CCRCC的分期有关。结论 CCRCC合并MS者病理分期较高、分级较低、肿瘤更大,糖尿病、高血压和血脂紊乱都可增加CCRCC的病理分期。
OBJECTIVE The metabolic syndrome（MS） is a set of clinical syndrome, MS and its related components has close relationship with cancer development. This study aimed to analyze the correlation of metabolic syndrome and its related com- ponents with stage, grade and tumor size of clear cell renal cell carcinoma（CCRCC）. METHODS Retrospective analysis on January 1, 2013 to December 30, 2015 in the first hospital of shanxi medical university and the pathological diagnosis of CCRCC of the clinical data of 375 patients, including age, gender, height, weight, blood pressure, fasting blood glucose, biochemical results, tumor staging and tumor size. Count data using X^2 test, measurement data with x±s, were compared by t test,multiple factors analysis using logistic regression analysis. RESULTS There were 56 patients in the MS group, including 32 cases of male patients, 24 female patients, 319 cases of patients with non MS group, including 206 cases of male patients, 113 female patients, male and female were compared, the difference was not statistically significant （P= 0. 287）. There was no significant difference between MS group and non MS group in age, smoking and drinking etc （P= 0. 100, P= 0. 691, P= 0. 269）, but BMI index, diastolic blood pressure, fasting blood glucose, TG and H DL-C had significant differences （P〈0. 001）. The pathological features of MS, compared with non MS CCRCC pathological staging and tumor size were significantly different （P= 0. 018, P= 0. 026, P= 0. 026）. Diabetes, hypertension and dyslipidemia had the inferences on CCRCC staging （P〈0. 001, P=0. 015, P=0. 006）. CONCLUSIONS Patients with CCRCC combined with MS have higher stage, lower grade and larger tumor size. Diabetes, hypertension and dyslipidemia can increase the pathological stage of CCRCC.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2017年第6期398-402,共5页
Chinese Journal of Cancer Prevention and Treatment
关键词
代谢综合征
肾细胞癌
肾透明细胞癌
病理分级分期
肿瘤大小
metabolic syndrome
renal cell carcinoma
clear cell renal cell carcinoma
pathological
tumor size
