摘要
胃肠道息肉是指黏膜上皮或腺体过度增生形成的良性肿瘤,既可单发亦可多发,是胃肠道的癌前病变,也是消化内科的常见病。血脂异常是指人体血液中胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白(LDL)等脂类物质出现的异常状态,是一种与肥胖高度相关的代谢紊乱。近年来,关于胃肠道息肉受代谢性因素影响的研究较多,根据文献报道,大部分胃肠道息肉患者都存在血脂异常的现象,由此可以推测合理使用降脂药物对于胃肠道息肉患者有一定的预防作用。然而在各种研究中,究竟哪种脂类成分与息肉的发病有关,目前尚无定论。本文拟从血脂异常与胃肠道息肉发病的关系入手,重点探讨血脂异常和胃肠道息肉之间潜在发病机制、与胃肠道息肉的相关性以及降脂药物在胃肠道息肉中的应用等方面的研究进展进行综述。为临床上更早筛选出胃肠道息肉并及时阻断其发展提供参考。
Gastrointestinal polyp refers to a benign tumor formed by excessive hyperplasia of mucosal epithelium or glands,which can be single or multiple.It is a precancerous lesion of gastrointestinal tract and a common disease in gastroenterology.Dyslipidemia refers to the abnormal state of cholesterol(TC),triglyceride(TG)and low density lipoprotein(LDL)in human blood,which is a metabolic disorder highly associated with obesity.In recent years,there have been many researches on gastrointestinal polyps impacted by metabolic factors.According to literature reports,most patients with gastrointestinal polyps have dyslipidemia,from which we can infer that rational use of lipid-lowering drugs has a certain preventive effect on patients with gastrointestinal polyps.However,in various research,there is currently no consensus on which lipid component is related to the pathogenesis of polyps.Starting with the correlation between dyslipidemia and gastrointestinal polyp occurrence,the potential pathogenesis between dyslipidemia and gastrointestinal polyps,the correlation with gastrointestinal polyps,and the application of lipid-lowering drugs in gastrointestinal polyps and other research progresses were investigated,focused and reviewed on this paper.Some clinical reference for screening gastrointestinal polyps earlier and blocking their development in time are provided.
作者
王一朗
杨文颖
周姝妤
WANG Yilang;YANG Wenying;ZHOU Shuyu(Changchun University of Chinese Medicine,Jilin,Changchun 130117,China;Jilin Province People’s Hospital,Jilin,Changchun 130117,China)
出处
《中国医药科学》
2024年第16期41-44,共4页
China Medicine And Pharmacy
关键词
胃肠道息肉
血脂异常
降脂药物
相关性
Gastrointestinal polyps
Dyslipidemia
Lipid-lowering drugs
Co rrelation
