摘要
氧化还原信号是细胞内稳态的重要调节因素,许多生物过程响应来自细胞内氧化还原状态的信号。研究发现细胞氧化还原状态在体内发生节律性振荡,周期与节律基因振荡周期一致。大量证据表明昼夜节律的转录/翻译反馈回路机制与氧化还原的非转录振荡机制间存在相互调控关系,二者耦合产生一个具有高度灵活性的计时系统。空间飞行期间,航天员长期暴露于微重力环境会造成昼夜节律失调和机体氧化应激损伤,增加健康风险,导致航天员任务执行能力下降,警觉性降低。目前微重力环境对氧化应激的影响已有较为深入的研究,但微重力对昼夜节律的影响研究较少,两者相互作用的分子机制仍未完全阐明。综述了节律基因的转录振荡与氧化还原的非转录振荡,总结了二者的调控关系以及微重力对昼夜节律和氧化还原的影响,可为进一步深化空间生物学研究和制定航天医学综合防护措施提供借鉴。
Redox signal is an important regulator of intracellular homeostasis and many biological processes are capable to response to it.Studies have demonstrated that redox oscillates in the body and its period is consistent with that of the clock genes.With the deepening of the researches,large amount of evidence indicates that the transcriptional/translational feedback loops mechanism of circadian rhythm and the non-transcriptional oscillatory mechanism of redox are mutually regulated.The two mechanisms therefore are coupled to produce a timing system with high flexibility.Long-term exposure to microgravity can cause circadian rhythm disorders and oxidative stress damages to the body,increase the health risks of astronauts,and lead to a decline in mission performance and alertness.At present,the effect of microgravity environment on oxidative stress has been studied in depth,but the effect of microgravity on the molecular mechanism of circadian rhythm is rarely studied,and the molecular mechanism of interaction between them has not been fully elucidated.In this paper,the transcriptional oscillation of clock genes and non-transcriptional oscillation of redox were reviewed,the regulation relationship between them and the influence of microgravity on them were summarized.It may serve as a good reference for further deepening the research of space biology and formulating the comprehensive countermeasures of space medicine.
作者
黄超
陈海龙
宋波
曲丽娜
Huang Chao;Chen Hailong;Song Bo;Qu Lina(不详;State Key Laboratory of Space Medicine Fundamentals and Application,China Astronaut Research and Training Center,Beijing 100094,China;Department of Pathology and Forensics,Dalian Medical University,Dalian Liaoning 116044,China)
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2021年第1期80-88,共9页
Space Medicine & Medical Engineering
基金
国家自然科学基金项目(31800998)
中国载人航天工程航天医学实验项目(HYZHXM03006)
航天医学基础与应用国家重点实验室项目(SMFA17A03,SMFA19K08)。
