摘要
大量数据表明,活性氧和氧化还原信号在心血管疾病的发生发展中起到重要作用。而活性氧可由NADPH氧化酶(Nox)生成。Nox包括有Nox1、Nox2、Nox3、Nox4、Nox5以及Duox1和Duox2,其中Nox1、Nox2和Nox4在心血管疾病的发生发展中研究较多,而Nox5由于未知原因在啮齿动物的进化过程消失,导致对Nox5的研究以及其作用知之甚少。在之前的研究中,未见Nox5的相关详细报道,但近来有新的研究表明,Nox5参与多种心血管疾病的发生。
A lot of researches show that reactive oxygen species and redox signals are crucially involved in the occurrence and development of cardiovascular diseases.And the reactive oxygen species can be generated by NADPH oxidases(Noxs).Noxs include Nox1,Nox2,Nox3,Nox4,Nox5,Duox1 and Duox2.Among them,Nox1,Nox2 and Nox4 have been studied in the occurrence and development of cardiovascular diseases,while Nox5 has disappeared in the evolutionary process of rodents due to unknown reasons,leading to little knowledge of Nox5 and its effects.In previous studies,no detailed reports about Nox5 have been seen,yet recent studies have shown that Nox5 is involved in a variety of cardiovascular diseases.
作者
李丹
徐蔓
唐其柱
LI Dan;XU Man;TANG Qizhu(Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China)
出处
《心血管病学进展》
CAS
2020年第12期1302-1305,共4页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(81530012)
湖北省自然科学基金(2019CFB179)。
