摘要
Functionalization of mesoporous silica spheres with well-dispersed and ultra-small nanodots to exert their synergistic effects for biomedical applications has been considered to be an urgent challenge.Herein,homogeneously incorporation of ultra-small and monodispersed MoS_(2) nanodots in the mesoporous silica nanospheres(MSN)was achieved by a facile one-step solvothermal reaction.The as-synthesized UsMSND@MSN possessed uniform size(~115 nm)and favorable biocompatibility inherited from MSN.The dispersed UsMSND within MSN could act as anchoring sites for aromatic anti-cancer drug DOX loading,and consequently achieved pH-responsive release based on the specialπ-π/electrostatic interactions with the DOX molecules.More importantly,the well-dispersed UsMSND in MSN could function as the non-toxic contrast agent for the sensitive in vivo CT imaging in various tumors including breast cancer and glioma with different sections.This work promises a good strategy for dispersed incorporation of UsMSND into MSN as an excellent pH-responsive platform for simultaneous cancer imaging and therapy.
基金
supported by National Natural Science Foundation of China(31922044,21675032,81861138040 and 81773280)
Natural Science Foundation of Shanghai(19ZR1471600)
the Fundamental Research Funds for the Central Universities and DHU Distinguished Young Professor Program and Minhang Hospital Collaboration Fund(RO-MY201802)。
