摘要
Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties,and is an active area of ongoing research readily applicable to nanoscale biomedicine.Nanoparticles(NPs)coated with cell membranes offer an opportunity to unite natural cell membrane properties with those of the artificial inner core material.The coated NPs not only increase their biocompatibility but also achieve effective and extended circulation in vivo,allowing for the execution of targeted functions.Although cell membrane-coated NPs offer clear advantages,much work remains before they can be applied in clinical practice.In this review,we first provide a comprehensive overview of the theory of cell membrane coating technology,followed by a summary of the existing preparation and characterization techniques.Next,we focus on the functions and applications of various cell membrane types.In addition,we collate model drugs used in cell membrane coating technology,and review the patent applications related to this technology from the past 10 years.Finally,we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology.
Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research readily applicable to nanoscale biomedicine. Nanoparticles(NPs) coated with cell membranes o er an opportunity to unite natural cell membrane properties with those of the artificial inner core material. The coated NPs not only increase their biocompatibility but also achieve e ective and extended circulation in vivo, allowing for the execution of targeted functions. Although cell membrane?coated NPs o er clear advantages, much work remains before they can be applied in clinical prac?tice. In this review, we first provide a comprehensive overview of the theory of cell membrane coating technology, followed by a summary of the existing preparation and characterization techniques. Next, we focus on the functions and applications of various cell membrane types. In addition, we collate model drugs used in cell membrane coating technology, and review the patent applications related to this technology from the past 10 years. Finally, we survey future challenges and trends pertaining to this technology in an e ort to provide a comprehensive overview of the future development of cell membrane coating technology.
基金
financially supported through grants from the Guangdong Provincial Natural Science Foundation of China(No.2018A030310623)
the Research Fund of University of Macao(MYRG2018-00207-ICMS and SRG2017-00095ICMS)
the National Natural Science Foundation of China(No.81673627).
