摘要
Mesoporous silica nanoparticles(MSNs)are recognized as a prime example of nanotechnology applied in the biomedical field,due to their easily tunable structure and composition,diverse surface functionalization properties,and excellent biocompatibility.Over the past two decades,researchers have developed a wide variety of MSNs-based nanoplatforms through careful design and controlled preparation techniques,demonstrating their adaptability to various biomedical application scenarios.With the continuous breakthroughs of MSNs in the fields of biosensing,disease diagnosis and treatment,tissue engineering,etc.,MSNs are gradually moving from basic research to clinical trials.In this review,we provide a detailed summary of MSNs in the biomedical field,beginning with a comprehensive overview of their development history.We then discuss the types of MSNs-based nanostructured architectures,as well as the classification of MSNs-based nanocomposites according to the elements existed in various inorganic functional components.Subsequently,we summarize the primary purposes of surface-functionalized modifications of MSNs.In the following,we discuss the biomedical applications of MSNs,and highlight the MSNs-based targeted therapeutic modalities currently developed.Given the importance of clinical translation,we also summarize the progress of MSNs in clinical trials.Finally,we take a perspective on the future direction and remaining challenges of MSNs in the biomedical field.
基金
supported by the National Key Research and Development Program of China(Grant No.2021YFC2102900)
the National Natural Science Foundation of China(Grant Nos.U21A2085,82072406 and 22061130205)
the Fundamental Research Funds for the Central Universities and Research Projects on Biomedical Transformation of China-Japan Friendship Hospital(No.XK2022-08)
the Open Foundation of State Key Laboratory of Organic-Inorganic Composites,Beijing University of Chemical Technology(No.OIC-202201010)
the China National Postdoctoral Program for Innovative Talents(No.BX20220028)
the China Postdoctoral Science Foundation(2022M720015)
the Beijing Municipal Health Commission(BJRITO-RDP-2023)
Beijing Jishuitan Hospital Elite Young Scholar Programme(XKGG2021).
